wangyue@nankai.edu.cn【Abstract】 Objective By co-cultivation of murine macrophage cells(RAW264.7)with breast carcinoma cells (4T1)to investigatethe inductive effects of IL-6on transformation of M1 macrophages to tumor-associated M2 macrophages.Methods Three groups were setup in present study:group ...
10. Tardito, S. et al. Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review. Autoimmun. Rev. 18, 102397 (2019). 11. Locati, M., Curtale, G. & Mantovani, A. Diversity, Mechanisms, and Sig...
Conclusion: Intermittent hypoxia acts as a potent proinflammatory stimulus, resulting in IL-6 induction and M1 macrophage polarization. Increased IL-6 expression may be due to both induction of antioxidant response element and nuclear factor kappa B as well as inhibition of miR-365 expression. ...
Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), enhance macrophage activation and antigen presentation, inducing osteoclast formation and regulating inflammation through different mechanisms17,18. IL-6 is assumed to be the “classic” pro-inflammatory ...
The supernatant of STAT5A1*6-transduced cells contained sufficient concentrations of IL-6 to induce macrophage differentiation of parental M1 cells, and STAT3 was phosphorylated on their tyrosine residues in these cells. Treatment of the cells with anti-IL-6 blocking Abs profoundly inhibited the ...
细胞诱导分化macrophages机制removalling 目录 缩略语表...1 英文摘要...
( P <0.05).As compared with those in group B, the expression levels of M2 macrophage related cytokines-CCL22 and IL-10 mRNA and protein were significantly up-regulated in group C ( P <0.05),but the expression levels of M1 macrophage related cytokines-IL-12, TNF-α lpha mRNA and ...
In conclusion, IL-6 cooperated with M-CSF could induce CD14+monocytes differentiate to M2-like(IL-10 high TGF-β high IL-12 low ) macrophages by activating STAT3 signal pathway.[Key words] IL-6; STAT3; Macrophage; M2 polarization巨噬细胞是免疫系统的主要组成部分,其发挥重要的防御功能。对巨...
IL-6 activated STAT1 in a dose- and time-dependent man-ner inM1, R2 and U937 cellswhich underwent growth arrest andmacrophage differentiation upon IL-6 induction.CONCLUSION:These results suggest that IL-6-induced STAT1 activation mightbe associated with growth-inhibitory effects, and our data migh...
(P <0. 05). As compared with those in groupB,the expression levels of M2 macrophage related cytokines-CCL22 and IL-10 mRNA and protein were significantlyup-regulated in group C (P < 0. 05),but the expression levels of M1 macrophage related cytokines-IL-12,TNF-α lphamRNA and protein...