Conclusion: Intermittent hypoxia acts as a potent proinflammatory stimulus, resulting in IL-6 induction and M1 macrophage polarization. Increased IL-6 expression may be due to both induction of antioxidant response element and nuclear factor kappa B as well as inhibition of miR-365 expression. ...
10. Tardito, S. et al. Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review. Autoimmun. Rev. 18, 102397 (2019). 11. Locati, M., Curtale, G. & Mantovani, A. Diversity, Mechanisms, and Sig...
Contents lists available at ScienceDirectCancer Lettersjournal homepage: www.elsevier.com/locate/canletOriginal ArticlesIL-6 induced M1 type macrophage polarization increases radiosensitivity inHPV positive head and neck cancerXiaohang Chen a,b , Enhui Fu a , Huihuang Lou a , Xionghui Mao c , Bin...
The IL-4R is an integral component of the receptor complexes for the cytokines IL-4 and IL-13, which are needed for M2 macrophage differentiation. Therefore, in the context of obesity, elevated IL-6 serum levels rather seem to counterbalance obesity-associated hyperglycemia. Interestingly, also ...
Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), enhance macrophage activation and antigen presentation, inducing osteoclast formation and regulating inflammation through different mechanisms17,18. IL-6 is assumed to be the “classic” pro-inflammatory ...
This pathway is favored by the induced production of granulocyte-macrophage colony-stimulating factor (GM-CSF) at pulmonary perivascular locations, which promotes the differentiation of newly recruited monocytes into moDCs that are well-equipped to detect LPS and other PAMPs and produce proinflammatory ...
e Elisa analysis of IL-6 showed changes in macrophage IL-6 expression over time after IL-6 stimulation. f & g Cell migration, invasion and proliferation ability of LUAD cells (A549 and H358) alone, co-culture with M2-like macrophages or co-culture with M2-like macrophages and stimulated ...
( P <0.05).As compared with those in group B, the expression levels of M2 macrophage related cytokines-CCL22 and IL-10 mRNA and protein were significantly up-regulated in group C ( P <0.05),but the expression levels of M1 macrophage related cytokines-IL-12, TNF-α lpha mRNA and ...
本文件规定了细菌脂多糖诱导单核巨噬细胞RAW 264.7分泌炎症因子IL-6含量测试方法的原理、材料、试验方法、结果计算、质量控制、结果评价和报告。 本文件适用于具有舒缓功效的化妆品及化妆品原料。《化妆品舒缓功效评价 脂多糖诱导巨噬细胞炎症因子IL-6测定方法》, Soothing
In conclusion, IL-6 cooperated with M-CSF could induce CD14+monocytes differentiate to M2-like(IL-10 high TGF-β high IL-12 low ) macrophages by activating STAT3 signal pathway.[Key words] IL-6; STAT3; Macrophage; M2 polarization巨噬细胞是免疫系统的主要组成部分,其发挥重要的防御功能。对巨...