bone marrow-derived macrophages and macrophage cell lines and also reported M2could express higher IL-10 than M1.So IL-10 is as one of bio-markers of M2 in the references usually.Objective: To investigate the e
Macrophages play a crucial role in immune responses and undergo metabolic reprogramming to fulfill their functions. The tetramerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) induces the production of the anti-inflammatory cytokine interleukin (IL)-10invivo, but the underlying mechanism remai...
The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). M1 and M2 macrophages (Mφ) were differentiated with granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating ...
细胞数量和肿瘤质量也降低。在服用S3QEL 1.2后,浸润肿瘤的M1型巨噬细胞主要组织相容性复合物II类(MHCII)分子的表达增加(图5F),这与向CD4+ T细胞呈现肿瘤抗原有关,而M2型巨噬细胞的存在在同一组中则出现中度下降(图5G)。肿瘤浸润巨噬细胞产生的IL-10受到S3QEL 1.2的抑制(图5H)。S3QEL 1.2给药后,肿瘤浸润...
n–p M1, M2-, and DAM-phenotype profile of microglia in Il-10-expressing M83+/+ mice compared to GFP-expressing M83+/+ control mice. **P < 0.01. n = 3 mice/group. In the box plot, the whiskers extend from the minimum to maximum values, with the midline representing the ...
M1 and M2 macrophages promote the differentiation of neighboring cells to their common activation state and inhibit activation of the others. The same cells can, to some extent, be reversed from one to another functional phenotype. Moreover, the dynamic changes in macrophage phenotype frequently ...
Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal cord injury Acupunct. Med., 35 (2017), pp. 224-230 CrossrefView in ScopusGoogle Scholar [36] M.D. Da Silva, F. Bobinski, K.L. Sato, S.J. Kolker, K.A. Sluka, A.R. Santos IL-...
For example, IL-10 derived from M2 macrophages was found to regulate proliferation and invasion in gastric cancer cells [14]. It has also been reported that increased IL-10 mRNA expression in tumor-associated macrophage correlated with the progression of lung cancer [30]. Our study investigates ...
inflammatory leukocytes have also been reported in inflammatory myositis [10,11,12,13,14] and in exercise-induced muscle damage [15,16,17]. Macrophages efferocytosis and the transition from M1 to M2 phenotype are causally related and represent the limiting steps for muscle repairing. Macrophages ...
2d, e), suggesting that glutamate metabolism characterizes B-lineage cells in both species. Fig. 2: Mouse and human B cells synthesize and secrete GABA. a, MS analysis of glutamine, glutamate and GABA in purified CD4+ T cells, CD8+ T cells, CD11b+ and/or CD11c+ macrophages and ...