bone marrow-derived macrophages and macrophage cell lines and also reported M2could express higher IL-10 than M1.So IL-10 is as one of bio-markers of M2 in the references usually.Objective: To investigate the expression of IL-10 under M1, M2 state in four kinds macrophages and choose the...
The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). M1 and M2 macrophages (Mφ) were differentiated with granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating ...
n–p M1, M2-, and DAM-phenotype profile of microglia in Il-10-expressing M83+/+ mice compared to GFP-expressing M83+/+ control mice. **P < 0.01. n = 3 mice/group. In the box plot, the whiskers extend from the minimum to maximum values, with the midline representing the ...
The production of high levels of IL-10 but low levels of IL-12 has previously been associated with an M2b or ‘regulatory’ macrophage phenotype, which was initially described in macrophages stimulated with a combination of immune complexes and LPS. We found that zymosan, via dectin-1 ...
Macrophages up-regulated the expression of prolymphangiogenic vascular endothelial growth factor-C upon stimulation with IL-10. Consistently, corneal inflammation resulted in reduced expression of vascular endothelial growth factor-C and decreased corneal lymphangiogenesis in IL-10–deficient mice (IL-10...
In addition, macrophages from mice 18 months or older polarize more readily to an alternatively activated phenotype14,26. Adoptive transfer of M1-like young syngeneic macrophages, but not M2-like old macrophages, into old recipient mice resulted in significant reduction of CNV in a murine model ...
2). In addition, the majority of kidney-resident macrophages also displayed the same functional similarity as M2 macrophages. They all have powerful anti-inflammatory, tissue repair, and tubular regeneration-promoting effects during kidney injury [57]. These macrophages originate early from embryonic ...
Poultry ScienceALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophagespubmed:27486255 Future MicrobiologyTransplantation of a bacterial consortium ameliorates trinitrobenzenesulfonic acid-induced colitisand intestinal dysbiosis in rats.pubmed:27415182 ...
macrophages by decreasing TLR4- MyD88-NF-κB signaling pathway and by regulating a series of cytokine production and miRNA expression.24,25 In a spinal cord injury (SCI) rat model TNA inhibited the expression of pro-inflammatory factors and related pathways, ameliorated apoptosis, and reversed the...
This restoration to homeostasis requires the coordinated recognition and pha- gocytosis of apoptotic cells by macrophages and, in experi- mental models, the production of anti-inflammatory cytokines 1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of ...