Whether other IFN-dependent signals may also contribute to such an unconventional circumstance of M2-like macrophage skewing remain unexplored. Herein, we first unveil IL-6 as another ligand that participates in IFN-dependent induction of a typical M2 marker (ARG1) in transitional monocytes. Indeed,...
of M2 macrophage infiltration in cancer tissues. In order to explore whether IL-6 have an 第三军医大学硕士学位论文 4 effect on M2 macrophages polarization, we established macrophage differentiation model in vitro. Through detecting the phenotype of the IL-6 induced macrophage, we found that...
The IL-4R is an integral component of the receptor complexes for the cytokines IL-4 and IL-13, which are needed for M2 macrophage differentiation. Therefore, in the context of obesity, elevated IL-6 serum levels rather seem to counterbalance obesity-associated hyperglycemia. Interestingly, also ...
In conclusion, IL-6 cooperated with M-CSF could induce CD14+monocytes differentiate to M2-like(IL-10 high TGF-β high IL-12 low ) macrophages by activating STAT3 signal pathway.[Key words] IL-6; STAT3; Macrophage; M2 polarization巨噬细胞是免疫系统的主要组成部分,其发挥重要的防御功能。对巨...
¥2200/100 μL Cat No.21865-1-AP 浓度:650 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy See more citations ...
(HEMC-1) and human umbilical vein endothelial cells (HUVECs) to examine the effect of USP24 on angiogenesis. The tube-formation ability was increased after incubation with M2 macrophage-derived conditioned medium. However, this effect was prevented after USP24 knockdown in the M2 macrophages (Fig...
Our results show, for the first time, that IL-6 is a key cytokine that drives monocyte recruitment and determines the establishment of the M2 cardiac macrophage profile during infection. This cytokine induced in vivo and in vitro expression of the ATP metabolic enzyme CD39 on macrophages, ...
10. Tardito, S. et al. Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review. Autoimmun. Rev. 18, 102397 (2019). 11. Locati, M., Curtale, G. & Mantovani, A. Diversity, Mechanisms, and Sig...
本研究结果显示,宫颈癌细胞上清可抑制巨噬细胞M1型细胞因子如IL-1β及IL-6的表达,而促进M2型细胞因子如IL-10和CCL22的表达,从而使巨噬细胞呈现肿瘤支持性的M2型分泌谱。这与之前在肿瘤组织中观察到的现象一致。而经LPS作用后,宫颈癌细胞上清...
结论 将RAW264.7细胞和KM3细胞共培养后,后者能诱导RAW264.7细胞向肿瘤相关M2型巨噬细胞转化, IL-6在上述转化过程中发挥重要作用.%Objective To investigate the effects of IL-6 in polarization process of macrophages to M2 type,with macrophage cell line-RAW264.7 of mice being co-cultured with myeloma ...