Fig 1g:小鼠 IL-1β+ TAMs 表达 CD64, CD11c, MHCII 和共刺激分子 CD80 和 CD86, 以及肿瘤中的免疫失调marker 如CD206,ARG1和免疫检查点抑制剂PD-L1。 Thus, IL-1β+ TAMs are a conserved macrophage population that co-expresses inflammatory and immune inhibitory markers. Fig 1 3. A monocytic ori...
此外,IL-1促进肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)的免疫抑制和肿瘤促进功能。TAM上调内皮细胞粘附分子和趋化因子(如 CCL2)。IL-1可以诱导TAM的M2免疫抑制表型,导致T细胞介导的抗肿瘤效应受损. IL-1可以激活血管内皮细胞中的促炎-促血栓程序,并诱导血管生成介质的产生。 在胰腺癌模型中,IL-1b被...
MDC/CCL22(Mouse Macrophage-Derived Chemokine) ELISA Kit 小鼠巨噬细胞来源的趋化因子Multi-class antibodies规格: 48T RANTES/CCL5(Mouse regulated on activation in normal T-cell expressed and secreted) ELISA Kit 小鼠正常T细胞表达和分泌因子Multi-class antibodies规格: 48T 小鼠白介素 1(IL-1)ELISA 试...
we showed that macrophage-derived soluble factors induce canonical Wnt signaling in colon cancer cells and promote their growth. Tumor cells induced the release of interleukin (IL)-1β from macrophages, which induced phosphorylation of GSK3β, stabilized β-catenin, enhanced T-cell factor (TCF...
strategy for treating macrophage-related inflammatory diseases. 神经递质已被充分证明可以决定免疫细胞的命运;然而,γ-氨基丁酸 (GABA) 是否以及如何影响先天免疫细胞的功能仍不清楚。在这里,我们证明 GABA 协调巨噬细胞成熟和炎症。巨噬细胞成熟过程中的 GABA 处理可抑制炎症性巨噬细胞产生白细胞介素 (IL)-1β。
Levels of macrophage colony-stimulating factor (M-CSF), interleukin-1 (IL-1), interleukin-6 (IL-6) and TNF alpha in human ovarian cancer - European Journal of Cancer and Clinical Oncologydoi:10.1016/0277-5379(91)91539-UM.M. Moradl
Our in vitro results imply that natural aspecific immunity and its relation to the secretory function of the macrophage might be crucial for the prevention of the initial assault responsible for the onset of the immune process leading to . 展开 ...
(2-DG), results in a decrease of macrophage pro-inflammatory cytokine production3,4. Similarly, the immunosuppressive cytokine IL-10 inhibits effector functions of classically activated macrophages by decreasing glycolysis5. Consistent with the impact on inflammatory response, glycolysis inhibition offers ...
In this study, we demonstrate that fibroblasts grown from histologically normal human duodenal biopsy tissues expressed mRNA genes for granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, intercellular adhesion molecule-1 (ICAM-1) and vas...
In addition, expression of the IL-1β and CLR genes was increased in ST, but was decreased upon macrophage depletion, and the IL-1β treatment of cultured synovial cells up-regulated CLR. Taken together, the present findings suggest that synovial macrophages are the major producers of IL-1β...