之前已经有研究证明了mTORC1(雷帕霉素靶蛋白复合物1)的激活可通过抑制巨噬细胞的自噬和增加其凋亡来促进动脉粥样硬化形成。 近期,来自匹兹堡大学医学院的Babak Razani团队在Circulation Research杂志上发表了题为Loss of Macrophage mTORC2 ...
The first objective of our study was to characterize IL-1b-positive MVs obtained from macrophage cell culture supernatants and to investigate their biological functions in vitro and in vivo. The second objective was to detect circulating IL-1b-positive MVs in JIA patients. Met...
3. Dror, E., Dalmas, E., Meier, D.T., Wueest, S., The´ venet, J., Thienel, C., Timper, K., Nordmann, T.M., Traub, S., Schulze, F., et al. (2017). Postprandial macrophage-derived IL-1b stimulates insulin, and both synergistically promote glucose disposal and inflammation...
IL-1β信号受诱骗受体IL1-RII和受体拮抗剂IL1RA的负调控。有三个主要水平的控制来限制IL-1β的潜在促炎活性：1）控制NALP3-炎症小体的合成和释放，控制IL-1β加工蛋白酶Caspase-1的激活；2）控制膜受体；3）调节激活的受体下游的信号转导。03IL-1β的信号通路图2.IL-1β信号转导[4]IL-1β的信号转导主...
11. ZHAO L, YE W, ZHU Y, et al. Distinct macrophage polarization in acute and chronic gout[J]. Lab Invest, 2022,102(10):1054-1063. 12. GRASSI F, MARINO R. The P2X7 receptor in mucosal adaptive immunity[J]...
MDC/CCL22(Mouse Macrophage-Derived Chemokine) ELISA Kit 小鼠巨噬细胞来源的趋化因子Multi-class antibodies规格: 48T RANTES/CCL5(Mouse regulated on activation in normal T-cell expressed and secreted) ELISA Kit 小鼠正常T细胞表达和分泌因子Multi-class antibodies规格: 48T 小鼠白介素 1(IL-1)ELISA 试...
货号12-7114-82 CNY3,772.00 有货 查看价格 批量或定制请求 Application Created with Sketch. 图:1/32 IL-1 beta (Pro-form) Antibody (12-7114-82) in Flow In vitro-cultured mouse monocytes unstimulated (left) or stimulated with LPS (right), in the presence of Protein Transport ...
下一步研究是鉴定角质细胞诱导因子(Keratinocyte chemoattractant,KC)或者巨噬细胞炎症蛋白2(macrophage inflammatory protein-2 ,MIP-2)嗜中性粒诱导因子是否介导嗜中性粒细胞向坏死区域的聚集。因为在缺血条件下,SIR在诱导心脏、肺和肝等的损毁过程中发挥主要作用,Chen等的结果为通过阻断IL-1α-IL-1R信号传递途径而限...
(2-DG), results in a decrease of macrophage pro-inflammatory cytokine production3,4. Similarly, the immunosuppressive cytokine IL-10 inhibits effector functions of classically activated macrophages by decreasing glycolysis5. Consistent with the impact on inflammatory response, glycolysis inhibition offers ...
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice. Nat. Commun. 7:13344. doi: 10.1038/ ncomms13344Monnerat, G. et al. Macrophage-dependent IL-1beta production induces cardiac arrhythmias in diabetic ... G Monnerat,ML Alarcon,L Vasconcellos,... - 《Nature Comm...