IL-1β被认定为维持淋巴及外周血不成熟髓系细胞(也称之为髓系抑制细胞MDSCs)生成、扩增、抑制功能的主要细胞因子。此外,IL-1促进肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)的免疫抑制和肿瘤促进功能。TAM上调内皮细胞粘附分子和趋化因子(如 CCL2)。IL-1可以诱导TAM的M2免疫抑制表型,导致T细胞介导的抗肿瘤...
In confirmation, treatment of Huh7 cells with the IL-1 receptor antagonist (anakinra) completely blunted macrophage-mediated hepcidin transcription in hepatocytes. Finally, detailed analysis of potentially involved signaling pathways points toward STAT3 and CEBPδ-mediated hepcidin induction independent of ...
摘要 Neurotransmitters have been well documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrate that GABA orchestrates macrophage maturation and inflammation. GABA treatment during ...
3. Dror, E., Dalmas, E., Meier, D.T., Wueest, S., The´ venet, J., Thienel, C., Timper, K., Nordmann, T.M., Traub, S., Schulze, F., et al. (2017). Postprandial macrophage-derived IL-1b stimulates insulin, and both synergistically promote glucose disposal and inflammation...
近期,来自匹兹堡大学医学院的Babak Razani团队在Circulation Research杂志上发表了题为Loss of Macrophage mTORC2 DrivesAtherosclerosis via FoxO1 and IL-1β Signaling的研究文章。该研究使用巨噬细胞特异性Rictor和mTOR缺陷小鼠,以探究mTORC...
小鼠白介素1(IL-1)ELISA试剂盒MIP-2(Mouse Macrophage Inflammatory Protein 2) ELISA Kit 小鼠巨噬细胞炎性蛋白2Multi-class antibodies规格: 48T OT(Mouse oxytocin) ELISA Kit 小鼠催产素Multi-class antibodies规格: 48T MIP-3 Beta/ELC/CCL19(Mouse macrophage inflammatory protein 3 Beta) ELISA Kit 小鼠巨...
货号12-7114-82 CNY3,772.00 有货 查看价格 批量或定制请求 Application Created with Sketch. 图:1/32 IL-1 beta (Pro-form) Antibody (12-7114-82) in Flow In vitro-cultured mouse monocytes unstimulated (left) or stimulated with LPS (right), in the presence of Protein Transport ...
Aug;48:86-101.[13]Batra R, Suh MK, Carson JS, Dale MA, Meisinger TM, Fitzgerald M, Opperman PJ, Luo J, Pipinos II, Xiong W, Baxter BT. IL-1β (Interleukin-1β) and TNF-α (Tumor Necrosis Factor-α) Impact Abdominal Aortic Aneurysm Formation by Differential Effects on Macrophage ...
11. ZHAO L, YE W, ZHU Y, et al. Distinct macrophage polarization in acute and chronic gout[J]. Lab Invest, 2022,102(10):1054-1063. 12. GRASSI F, MARINO R. The P2X7 receptor in mucosal adaptive immunity[J]...
下一步研究是鉴定角质细胞诱导因子(Keratinocyte chemoattractant,KC)或者巨噬细胞炎症蛋白2(macrophage inflammatory protein-2 ,MIP-2)嗜中性粒诱导因子是否介导嗜中性粒细胞向坏死区域的聚集。因为在缺血条件下,SIR在诱导心脏、肺和肝等的损毁过程中发挥主要作用,Chen等的结果为通过阻断IL-1α-IL-1R信号传递途径而限...