前者产生IL-2 、IL-3 、IFN-γ和淋巴毒素及粒细胞-巨噬细胞集落刺激因子(granulocy te-macrophage colony stimulating factor ,GM-CSF)等, 参与细胞免疫;而后者则产生IL-4 、IL-5 、IL-10 和IL-13 等细胞因子,辅助B 细胞产生抗体,参与体液免疫。某些病原菌只能被Th1或Th2 有效地抑制。 IL-1 、IL-6 ...
Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B. Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL...
2023年7月20日,来自瑞士伯尔尼大学的Stefan Freigang团队在Immunity杂志上发表了一篇题为Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis的文章,他们研究了侵袭性念珠菌病小鼠模型中不同髓系细胞亚群中IL-1Ra的表达及它们对抗真菌免疫的影响,证明...
3. Dror, E., Dalmas, E., Meier, D.T., Wueest, S., The´ venet, J., Thienel, C., Timper, K., Nordmann, T.M., Traub, S., Schulze, F., et al. (2017). Postprandial macrophage-derived IL-1b stimulates insulin, and both synergistically promote glucose disposal and inflammation...
10. MARTINEZ-NAVA G A, MENDEZ-SALAZAR E O, VAZQUEZ-MELLADO J, et al. The impact of short-chain fatty acid-producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis[J]. Clin Rheumatol, 2023,42...
IL-1β (Interleukin-1β) and TNF-α (Tumor Necrosis Factor-α) Impact Abdominal Aortic Aneurysm Formation by Differential Effects on Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):457-463.[14]Zhang D, Zheng H, Zhou Y, Tang X, Yu B, Li J. Association of IL-1...
(IL)-1β, in response to the Toll-like receptor 4-ligand lipopolysaccharide (LPS)1,2. Pharmacological inhibition of glycolysis induced, for instance, by the hexokinase inhibitor 2-deoxyglucose (2-DG), results in a decrease of macrophage pro-inflammatory cytokine production3,4. Similarly, the ...
IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, s...
通过构建小鼠乳腺原位移植瘤模型与IL1R2基因敲除小鼠模型,研究人员发现,中和性抗体阻断IL1R2表达或者敲除IL1R2基因,均可以显著减少同系免疫健全小鼠肿瘤组织中BCSC的富集,并惊奇地发现该抗体显著抑制肿瘤组织中肿瘤相关巨噬细胞(Tumor-associa...
2024年3月5日,复旦大学基础医学院生理与病理生理学系阮承超团队与合作者在Nature Communications期刊在线发表了题为“ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis...