Real-time PCR and Western blot examination indicated that IL-10 treatment significantly diminished the particle-induced IL-1β expression but promoted expression of CD163, transforming growth factor-β1, and CCR2. Furthermore, IL-10 significantly inhibited the ultra-high-molecular-weight polyethylene ...
nature publishing group ARTICLES IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis B Li, R Alli, P Vogel and TL Geiger Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this...
ARTICLES nature publishing group Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury Y Zhao1, Z Xiong1, EJ Lechner1, PA Klenotic2, BJ Hamburg1, M Hulver1, A Khare1, T Oriss1, N Mangalmurti3, Y Chan1, Y Zhang1, MA Ross4, DB ...
Macrophage activation by proinflammatory stimuli is suppressed by IL-10. We tested the hypothesis that IL-10 induces an alternative state of macrophage activation rather than solely mediating suppression. We therefore searched for genes the expression of which might be up-rather than downregulated in ...
IL-10, which is secreted by multiple cell types, has regulatory effects on macrophages, including decreasing their ability to kill some microorganisms. The experiments presented here test the hypothesis that endogenous IL-10 inhibits the ability of macrophages to kill the facultative intracellular bacter...
IL-10, in addition to being a cytokine synthesis-inhibitory factor, is a cytokine that exerts multiple effects on various cell types. Recombinant human migration inhibitory factor (MIF) inhibits the migration of human monocytes as well as that of guinea pig and murine macrophages. In addition, ...
This is achieved by adding a 3 day 'maturation culture' to the initial 6-7 day culture in the presence of GM-CSF and IL-4. Macrophage-conditioned ... NR A,D Reider,MH A~,... - 《Journal of Immunological Methods》 被引量: 2176发表: 1996年 ...
IL-10-STAT3-Galectin-3 Axis is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction 来自 钛学术 喜欢 0 阅读量: 104 作者:S Kohsuke,E Jin,K Masaharu,K Yoshinori,Y Naohiro,Y Tsunehisa,I Sarasa,M Hidenori,G Shinichi,K Hiroki ...
M1巨噬细胞（经典激活巨噬细胞），主要由LPS及IFNγ激活，分泌高水平的IL2及较低水平的IL10，主要起到促进炎症发生发展，杀菌及吞噬等作用。而M2巨噬细胞（交替激活巨噬细胞）主要由IL4炎症因子激活，主要通过分泌IL10等抗炎细胞因子抑制M1巨噬细胞，在伤口愈合及组织修复等进程中起作用。图2 M1/M2...
Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. Clin Sci (Lond) 2009;116:241-... J Deng,C James,L Patel,... - 《Clinical Science》 被引量: 53发表: 2009年 Tribbles, a cell-cycle brake that coordinates proliferation...