1)经典激活或M1巨噬细胞,它们是促炎细胞,并被脂多糖(LPS)单独或与Th1细胞因子(如IFN-γ,GM-CSF)联合极化,并产生促炎细胞因子,如白细胞介素-1β (IL-1β), IL-6, IL-12, IL-23和TNF-α; 2)交替激活或M2型巨噬细胞,具有抗炎和免疫调节作用,被Th2细胞因子IL-4和IL-13极化,产生IL-10和TGF-β等...
1)经典激活或M1巨噬细胞,它们是促炎细胞,并被脂多糖(LPS)单独或与Th1细胞因子(如IFN-γ,GM-CSF)联合极化,并产生促炎细胞因子,如白细胞介素-1β (IL-1β), IL-6, IL-12, IL-23和TNF-α; 2)交替激活或M2型巨噬细胞,具有抗炎和免疫调节作用,被Th2细胞因子IL-4和IL-13极化,产生IL-10和TGF-β等...
IL-10/Fc inhibits macrophage function and prolongs pancreatic islet xenograft survival [J]. Transplantation,1999,68:1775-1783.Feng X, Zheng XX, Yi S, Lehnert AM, Strom TB, O'Connell PJ: Il-10/fc inhibits macrophage function and prolongs pancreatic islet xenograft survival. Transp...
nature publishing group ARTICLES IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis B Li, R Alli, P Vogel and TL Geiger Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this...
Macrophage activation by proinflammatory stimuli is suppressed by IL-10. We tested the hypothesis that IL-10 induces an alternative state of macrophage activation rather than solely mediating suppression. We therefore searched for genes the expression of which might be up-rather than downregulated in ...
M1巨噬细胞(经典激活巨噬细胞),主要由LPS及IFNγ激活,分泌高水平的IL2及较低水平的IL10,主要起到促进炎症发生发展,杀菌及吞噬等作用。而M2巨噬细胞(交替激活巨噬细胞)主要由IL4炎症因子激活,主要通过分泌IL10等抗炎细胞因子抑制M1巨噬细胞,在伤口愈合及组织修复等进程中起作用。
IL-10, in addition to being a cytokine synthesis-inhibitory factor, is a cytokine that exerts multiple effects on various cell types. Recombinant human migration inhibitory factor (MIF) inhibits the migration of human monocytes as well as that of guinea pig and murine macrophages. In addition, ...
This is achieved by adding a 3 day 'maturation culture' to the initial 6-7 day culture in the presence of GM-CSF and IL-4. Macrophage-conditioned ... NR A,D Reider,MH A~,... - 《Journal of Immunological Methods》 被引量: 2176发表: 1996年 ...
Finally we show that the catalytic activity is required for EL to modulate the balance of macrophage IL-10 and IL-12 production. These results suggest that macrophage EL may play important roles in modulating the macrophage inflammatory response through local hydrolysis of HDL. 展开 ...
Marker:HLA-DPA1, HLA-DPB1, CD14, CD68, SELENOP, LYZ, C1QA, C1QB, (M0) CD209, CD163L1, FUCA1, MRC1, FOLR2, A2M, PTPRC, IL10RA, KLF4, NRG1, EREG, HBEGF, CD300E, VCAN, FCN1, INHBA, ACOD1, CXCL5, SPP1, MMP9, CLEC5A, S100A8, S100A9, OSM, TNF, IL1A, IL1B, ...