Anti-inflammatory effect of il-10 mediated by metabolic reprogramming of macrophages. Science. 2017; 356: 513-9.Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti- inflammatory effect of IL-10 mediated by metabolic reprogram- ming of macrophages. Science. 2017;356(...
Accordingly, HIF-1α and IL-1β are highly expressed in an LPS-induced in vivo model of acute inflammation using Arg2−/− mice. These findings shed light on a new arm of IL-10-mediated metabolic regulation, working to resolve the inflammatory status of the cell....
Like GABA, IL-10 has also been shown to elicit anti-inflammatory macrophages by metabolic reprogramming promoting OXPHOS25, and is known to be secreted by B cells and IgA+ plasma cells26,27. We observed that the IL-10 receptor A signalling pathway was upregulated in TAMs from WT mice compa...
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages Science, 356 (2017), pp. 513-519 CrossrefView in ScopusGoogle Scholar Jolly and Sattentau, 2004 C. Jolly, Q.J. Sattentau Retroviral spread by induction of virological synapses Traffic, 5 (2004), pp. 643-65...
Inflammation and metabolic dysfunction: Links to cardiovascular diseases 2012, American Journal of Physiology - Heart and Circulatory Physiology Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation 2011, Thrombosis and Haemostasis ATP-bindi...
pyruvate dehydrogenase kinase (PDK)-dependent glycolytic metabolism, which diminishes their tolerogenic function of IL-10 production [96,97]. LCMs were only recently described to participate in immune surveillance and neutrophil recruitment, and apart from analysis of the enrichment of metabolic pathways ...
It should be highlighted, that the phenotypic plasticity of macrophages is associated with the acquisition of appropriate biological functions in response to environmental stimuli, through changes in surface markers, gene expression profile, production of cytokines and chemokines, as well as metabolic ...
Objective-Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin ...
STRING is a web-based interface that could predict protein associations which can mean direct physical binding and can also mean indirect interaction such as participation in the same metabolic pathway or cellular process on the basis of genomic context, high-throughput experiments, co-expression and...
OBJECTIVE--Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin...