7. Du Plessis, N., Kleynhans, L., Thiart, L., Van Helden, P.D., Brombacher, F., Horsnell, W.G.C., and Walzl, G. (2013). Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol. 6, 931–941. https://doi.org/10.1038/mi.201...
摘要 Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to contribute to age-related diseases. Although aging-associated immune dysfunction, or immunosenescence, is known to contribute to this process, the underlying mechanism remains elusive. Here, we report that...
7. Du Plessis, N., Kleynhans, L., Thiart, L., Van Helden, P.D., Brombacher, F., Horsnell, W.G.C., and Walzl, G. (2013). Acute helminth infection enhances early macrophage mediated control of mycobacterial infection.Mucosal Immunol.6, 931–941. https://doi.org/10.1038/mi.2012.131...
7. Du Plessis, N., Kleynhans, L., Thiart, L., Van Helden, P.D., Brombacher, F., Horsnell, W.G.C., and Walzl, G. (2013). Acute helminth infection enhances early macrophage mediated control of mycobacterial infection.Mucosal ...
IL-4 和 IL-13 在交替激活的巨噬细胞中诱导 c-Myc 表达(MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression. Journal of Leukocyte Biology.),相反,LPS 诱导的 HIF-1α 上调与 c-Myc 下调同时发生Myc 。总体而言,在没有二次刺激的情况下,训练...
Loss of SHIP and induction of alternatively activated macrophage markers, Ym1 and arginase I (argI), were dependent on phosphatidylinositol 3-kinase (PI3K) activity and argI induction was dependent on the class IA PI3Kp110未 isoform. STAT6 was required to reduce SHIP proteidoi:10.1002/eji....
Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1. ...
IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure...
NKT cells regulate macrophage production of IL-1β via cytokine production. • Among cytokines secreted by NKT cells, GM-CSF and IL-4 inversely influence IL-1β production. • GM-CSF regulates LPS-mediated pro-IL-1β expression and inflammasome activation. • IL-4 enhances M2-polarization...
IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.靶...