1)经典激活或M1巨噬细胞,它们是促炎细胞,并被脂多糖(LPS)单独或与Th1细胞因子(如IFN-γ,GM-CSF)联合极化,并产生促炎细胞因子,如白细胞介素-1β (IL-1β), IL-6, IL-12, IL-23和TNF-α; 2)交替激活或M2型巨噬细胞,具有抗炎和免疫调节作用,被Th2细胞因子IL-4和IL-13极化,产生IL-10和TGF-β等...
In MKP‐1‐deficient macrophages treated with IL‐4 and IL‐13 to induce the anti‐inflammatory phenotype, the expression of phenotypic markers arginase 1, Ym‐1 and FGF2 was reduced as compared to wild‐type cells. In contrast, LPS‐induced expression of the pro‐inflammatory factors IL‐6 ...
Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macropha...
常见ELISA试剂盒系列:IL-1、IL-1α、IL-1β、IL-2、IL-2R、IL-27、IL-23、IL-17、IL-18、IL-9、IL-8、IL-6、IL-5、IL-4、IL-2、IL-13、IL-11、IL-10、IL-12P70、IL-12P40、IFN-ω、IFN-β、IFN-α、值IFN-γ、TNF-β、TNF-α、sICAM-1、LEP、MMP-3等. ...
(Fig.5a). The qRT-PCR results demonstrated thatIl4was the most significantly elevated factors uponMcamKO by both MMTV-Cre and K14-Cre (Figs.5band S9a). Il4 and Il13, which are secreted by MECs38, and downstream Stat6 are essential for promoting macrophage polarization and activation39,...
However, M2 macrophages, which are usually induced by IL-4 and IL-13, induce the secretion of anti-inflammatory cytokines such as IL-10 and arginase-1 (ARG-1) to inhibit inflammation and promote tissue repair [16], [17]. Macrophage polarization can be regulated by modulating the ...
cytokines such as interleukin-1 (IL-1), IL-6, IL-12, IL-23 and TNF-±, and 2) Alternatively activated or M2 macrophages, which are anti-inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL-4 and IL-13 and produce anti-inflammatory cytokines such as IL-10 and ...
IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages. J Reprod Immunol 2008; 78: 140–148. Article CAS PubMed PubMed Central Google Scholar Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M et al. Alternatively ...
If instead it is driven by Th2 cytokines interleukin (IL)-4 and IL-13, it undergoes alternate type 2 activation, which enhances endocytotic antigen uptake and presentation, mast cell and eosinophil involvement and type 2 granuloma formation, e.g. in response to parasitic and extracellular ...
Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol. 2005;174:1063–72. Article CAS PubMed Google Scholar Byrne AJ, Mathie SA, Gregory LG, Lloyd CM. Pulmonary ...