Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the “classically activated” M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as Mycobacterium tuberculosis. By contrast, “alternatively activat...
TSPO Modulates IL-4-Induced Microglia/Macrophage M2 Polarization via PPAR-γ PathwayNeonatal hypoxia-ischemiaMicroglia polarizationTSPOPPAR-γM2Microglia activation has been reported to be associated with pathogenesis of neuroinflammation, central nervous system damage, and degeneration diseases. With various ...
normalized neutrophil numbers,efferocytosis, M2-macrophage polarization as well as resolution of zymosan-induced hypersensitivity. In conclusion, IL-4-expressing eosinophils support the resolution of inflammation by enabling the development of an anti-inflammatory framework, which encloses proinflammatory regions...
PD-1 antibody therapy in gastric cancer. These findings highlight the role of IL-4-induced macrophage polarization and metabolic reprogramming in immune resistance and verify IL-4 as potential targets for improving treatment outcomes in gastric cancer patients. Similar content being viewed by others H...
Post-stroke treatment with argon attenuated brain injury,reduced brain inflammation and enhanced M2 microglia/macrophage polarization:a randomized controlled animal study[J]. Crit Care,2019,23(1):198. DOI: 10.1186/s13054-019-2493-7. [24] LIU X,LIU J,ZHAO S,et al. Interleukin-4 Is Essential...
Fig. 6. OxLDL-treated plasma cells accelerate M2 macrophage polarization. (A) The frequencies of CD138+ plasma cells and the expression levels of IL-4 were analyzed by flow cytometric (n = 4 mice per group). (B) The levels of IL-4 in plasma cell supernatant were analyzed by ELISA...
Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tol- erance via interleukin-4 (IL-... Yewei,Ji,Shengyi,... - 《Journal of Biological Chemistry》 被引量: 189发表: 2012年 Activation of natural killer T cells promotes M2 ...
cells after IL.4 仃 eatment. 4)SUMOylation of KLF4 promotes IL-4 treated BMDM M2 polarization. Key words:KLF4 SUMOylation macrophage polarization 6 万方数据 大连医科大学硕士学位论文 KLF4 的 SUMO 化修饰促进 I L-4 诱导巨噬细胞向 M2 型极 化 硕士研究生姓名:王克洲 指导教 师:邢嵘教授 程金...
题目:Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways 影响因子:6.68 分区:Q2 ;中科院2区 01 摘要 巨噬细胞介导的慢性炎症在心血管疾病中起着重要作用,包括加速钙化性主动脉瓣...
NKT cells regulate macrophage production of IL-1β via cytokine production. • Among cytokines secreted by NKT cells, GM-CSF and IL-4 inversely influence IL-1β production. • GM-CSF regulates LPS-mediated pro-IL-1β expression and inflammasome activation. • IL-4 enhances M2-polarization...