Xu, X.-Y. Shi et al., "M2-polarized tumor- associated macrophages promoted epithelial--mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL- 10 signaling pathway," Laboratory Investigation, vol. 93, no. 7, pp. 844-854, 2013....
Macrophages are also polarized into two specific phenotypes in response to signals present within individ- ual microenvironments. Pro-inflammatory M1Mϕs (classically activated), which are activated by LPS and IFN-gamma, secrete TNF-alpha, IL-12, IL-6 and inducible NO synthase (iNOS) and...
Macrophages and osteoclasts are important components of bone marrow, and their interaction regulates bone metabolism and is involved in the progression of bone-related diseases (Sun et al., 2021). Especially in inflammatory and immune environments, macrophages, as an origin of osteoclasts, influence ...
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells World journal of gastroenterology (2021) -4Comments doi: 10.3748/wjg.v27.i36.6079 issn: 1007-9327 pubmed: 34629821 Hai-Yan Cui,Jian-Sheng Rong,Ju Chen,Jie Guo,Jia-Qin Zhu,Mei Ruan,...
Figure 1. Long-term co-culture of healthy human monocytes with HCV-infected hepatoma cells leads to monocyte differentiation into macrophages characterized with increased expression of M2 markers. Huh7.5 cells or Huh7.5/JFH-1 cells were co-cultured with monocytes obtained from healthy donors for 7 ...
activated M2 subtype. M1-type macrophages can exert anti-tumor effects by producing active factors and pro-inflammatory cytokines such as interleukin 6 (IL-6), IL-12, and interferon-γ (IFN-γ) active. Conversely, M2-polarized macrophages exert tumor-promoting activity by producing anti-...
NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from
Herein, we present mechanistic proof that treatment with M2-polarized macrophages (M2 MΦ) can effectively prevent PTB [(HMGB1, n = 28 vs. HMGB1+M2 MΦ, n = 29) (p<0.05)] and neonatal mortality [(HMGB1, n = 20 litters vs. HMGB1+M2 MΦ, n = 14 litters) (p<0.001)] induced ...
M2-polarized macrophages are tumor-associated-macrophages (TAMs), which are important contents of tumor-infiltrating immune cells. Toll-like receptor 4 (TLR4) is a molecular biomarker of tumor aggressiveness and poor prognosis. Toll-like receptors (TLRs) have important roles in the immune system ...
Exosomal mi R-588 from M2 macrophages contributed to DDP resistance of gastric cancer cells. mi R-588 promoted DDP-resistant gastric cancer cell growth in vivo. mi R-588 was able to target cylindromatosis(CYLD) in gastric cancer cells. The depletion of CYLD reversed mi R-588 inhibition-...