Macrophage polarizationTumor microenvironmentNanocarriersNuclear receptor PPAR gammaNF-kappa BMacrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like ...
但是,如果M1期继续,就会造成组织损伤。因此,M2巨噬细胞分泌大量IL-10和TGF-β抑制炎症,有助于组织修复、重塑、血管新生和保持稳态。 下图总结了M2巨噬细胞亚群的刺激物、表面标记物、分泌的细胞因子和生物学功能。 图片来源:Macrophage Polarization in Physiological and Pathological Pregnancy. Front Immunol. 2019 Ap...
但是,如果M1期继续,就会造成组织损伤。因此,M2巨噬细胞分泌大量IL-10和TGF-β抑制炎症,有助于组织修复、重塑、血管新生和保持稳态。 下图总结了M2巨噬细胞亚群的刺激物、表面标记物、分泌的细胞因子和生物学功能。 图片来源:Macrophage Polarization in Physiological and Pathological Pregnancy. Front Immunol. 2019 Ap...
Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection M.,J.,Davis,... - 《Mbio》 - 2013 - 被引量: 271 Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/...
As one of the first arriving immune cells after dental implantation, Ms own the abilities to polarize into to a spectrum of diverse phenotypes, from "classically activated" M1 Ms to "alternatively activated" M2 Ms. Herein, it was hypothesized that M phenotypes dynamically adapt after dental impla...
巨噬细胞亚型在As斑块区的分布也有差异,通过转录组学和免疫组织化学方法比较了人类颈动脉斑块破裂时和稳定时巨噬细胞极化标志物基因的表达情况,结果表明在斑块破裂时M1和M2型巨噬细胞标志物基因出现了过表达,也就是说,巨噬细胞亚型在这个时期大量浸润。此外,还发现在破裂斑块的肩部区域M1型明显多于M2型,而在斑块的纤...
Macrophage polarization is increasingly recognised as an important pathogenetic factor in inflammatory and neoplastic diseases. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity. M2 macrophages contribute to tissue repair and promote Th2 responses. CD68 and CD163...
To determine M1 or M2 RAW 264.7, or primary Mφ function, following treatment with B16-F10 melanoma exosomes, assays to assess increased inducible nitric oxide synthase activity, indicative of M1 Mφ polarization, and increased arginase activity, indicative of M2 Mφ polarization, were performed. ...
1c). In contrast, addition of IL-4, which stimulates M2 polarization, led to a marginal and statistically insignificant increase in the size of the nucleus. Clearly, the size of the nucleus in the M1 state was found to be substantially smaller than that in the M2 state. These observations...
Vitexin + Verapamil treatment elevated arginase activity and lowered iNOS/NO production, resulting from a shift from M1 to M2 polarization of macrophages (affirmed by FACS data). Decreased NF-κB activity is also associated with increased M2 polarization (Camille and Dealtry, 2018) which is importa...