Macrophage PolarizationOsteoarthritis (OA) is a chronic inflammatory joint disease associated with aging, trauma, obesity and other pathogenic factors. It is a leading cause of pain and disability worldwide. Ma
In the present systematic review, detailed aspects of the activities and polarization properties of M1 and M2 macrophages have been reviewed for the first time in RA blood, synovial tissue and synovial fluids. The aim of the review is to give a comprehensive overview of the current literature av...
但是,如果M1期继续,就会造成组织损伤。因此,M2巨噬细胞分泌大量IL-10和TGF-β抑制炎症,有助于组织修复、重塑、血管新生和保持稳态。 下图总结了M2巨噬细胞亚群的刺激物、表面标记物、分泌的细胞因子和生物学功能。 图片来源:Macrophage Polarization in Physiological and Pathological Pregnancy. Front Immunol. 2019 Ap...
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been scarce
Signaling molecules such as JAK/STAT, PI3K/Akt, and MAPK pathways are also involved in M1 and M2 polarization. The JAK/STAT pathway is activated by cytokines such as IFN-γ and IL-4 and promotes the activation of STAT1 and STAT6, respectively. The PI3K/Akt pathway is activated in M2 mac...
在人和小鼠中观察到M1和M2巨噬细胞表型的不同生物学和生理特征 表格数据来源:Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018 Sep;233(9):6425-6440. 3、抗原提呈 巨噬细胞,还是抗原提呈细胞。巨噬细胞捕获、内吞和表达自身或外来抗原,提呈给其他免疫细胞,作为启...
However, its function in regulating the innate immune response and microglial/macrophage M1/M2 polarization in TBI has not been addressed. The present study aimed to evaluate the role of Mer in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI. Methods The ...
Macrophage polarization tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes 热度: m0 m1 m2 m3 M0 M1 M2 M3基本概念和含义详解 热度: AcceptedManuscript M1toM2MacrophagePolarizationinHB-EGFTherapyforNEC JiaWei,M.D.,GailE.Besner,M.D. ...
(ii) CST promoted M1–M2 polarization by decreasing expression of proinflammatory cytokines and increasing expression of ant-iinflammatory cytokines. Support or Funding Information Supported by grants from the VA (I01BX000323 to S.K.M.), and the NWO Gravitation Programme 2013 (ICI-024.002.009 ...
Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, has been implicated in the activation of macrophages. Here we show that Jmjd3 is...