Conversely, physalin D can also activate STAT6 and enhance STAT6 nuclear translocation for M2 polarization. Taken together, these results suggested that physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway.doi:10.1002/jcp.27537...
在人和小鼠中观察到M1和M2巨噬细胞表型的不同生物学和生理特征 表格数据来源:Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018 Sep;233(9):6425-6440. 3、抗原提呈 巨噬细胞,还是抗原提呈细胞。巨噬细胞捕获、内吞和表达自身或外来抗原,提呈给其他免疫细胞,作为启...
但是,如果M1期继续,就会造成组织损伤。因此,M2巨噬细胞分泌大量IL-10和TGF-β抑制炎症,有助于组织修复、重塑、血管新生和保持稳态。 下图总结了M2巨噬细胞亚群的刺激物、表面标记物、分泌的细胞因子和生物学功能。 图片来源:Macrophage Polarization in Physiological and Pathological Pregnancy. Front Immunol. 2019 Ap...
Signaling molecules such as JAK/STAT, PI3K/Akt, and MAPK pathways are also involved in M1 and M2 polarization. The JAK/STAT pathway is activated by cytokines such as IFN-γ and IL-4 and promotes the activation of STAT1 and STAT6, respectively. The PI3K/Akt pathway is activated in M2 mac...
However, its function in regulating the innate immune response and microglial/macrophage M1/M2 polarization in TBI has not been addressed. The present study aimed to evaluate the role of Mer in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI. Methods The ...
Macrophage polarization tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes 热度: m0 m1 m2 m3 M0 M1 M2 M3基本概念和含义详解 热度: AcceptedManuscript M1toM2MacrophagePolarizationinHB-EGFTherapyforNEC JiaWei,M.D.,GailE.Besner,M.D. ...
In the present systematic review, detailed aspects of the activities and polarization properties of M1 and M2 macrophages have been reviewed for the first time in RA blood, synovial tissue and synovial fluids. The aim of the review is to give a comprehensive overview of the current literature av...
(ii) CST promoted M1–M2 polarization by decreasing expression of proinflammatory cytokines and increasing expression of ant-iinflammatory cytokines. Support or Funding Information Supported by grants from the VA (I01BX000323 to S.K.M.), and the NWO Gravitation Programme 2013 (ICI-024.002.009 ...
To determine M1 or M2 RAW 264.7, or primary Mφ function, following treatment with B16-F10 melanoma exosomes, assays to assess increased inducible nitric oxide synthase activity, indicative of M1 Mφ polarization, and increased arginase activity, indicative of M2 Mφ polarization, were performed. ...
showed that 84 miRNAs and 47 miRNAs with weredownregulated during M1 macrophage polarization and that 11 miRNAs wereupregulated and 19 miRNAs were downregulated during M2 macrophage polarization.MiR-novel-3-nature and miR-27b-5p could promote expression of TNF-a which wasmarker gene of M1 ...