IL-4 和 IL-13 在交替激活的巨噬细胞中诱导 c-Myc 表达(MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression. Journal of Leukocyte Biology.),相反,LPS 诱导的 HIF-1α 上调与 c-Myc 下调同时发生Myc 。总体而言,在没有二次刺激的情况下,训练...
Moreover, SHIP levels are decreased in macrophages treated with IL-4 and in murine GM-CSF-derived and tumor-associated macrophages. Loss of SHIP and induction of alternatively activated macrophage markers, Ym1 and arginase I (argI), were dependent on phosphatidylinositol 3-kinase (PI3K) activity ...
3. Murray, P.J., and Wynn, T.A. (2011). Protective and pathogenic functions of macrophage subsets.Nat. Rev. Immunol.11, 723–737. https://doi.org/10. 1038/nri3073. 4. Qiao, Y., Giannopoulou, E.G., Chan, C.H., Par...
由于IL4R、IL13RA1 和 STAT6 的表达在衰老过程中下降,且 STAT6 的表达与人类的 UBE2T 和 BRCA1 呈正相关,作者接下来探讨了通过激活 2 型 IL-4 信号通路来靶向衰老细胞(图 1A、1B)。为此,作者使用由甲状腺素结合球蛋白(TBG)启动子驱动的腺相关病毒 8(AAV8)-TBG-Il4,诱导肝细胞特异性表达,在小鼠肝脏...
Nattectin induces M1 activation of macrophages. The influx of macrophages induced by Nattectin is totally dependent on IL-4 and IFN-γ. IL-4 is able to work as a coadjuvant with IFN-γ and IL-12 in the macrophage M1 polarization induced by Nattectin....
英文名称:ELISA Kit for Interleukin 4 (IL4) 分子式:电询 纯度:99 % 产地:中国/美国/德国 品牌:BioLegend,Cygnus,IBL,TSZ等国内外品牌 包装规格:96T/48T 货号:xyA077Gu 别名:电询 通用名:豚鼠白介素4(IL4)检测试剂盒 英文名:ELISA Kit for Interleukin 4 (IL4) ...
In this study, we established macrophages that continuously secrete IL-4, and found that single pulmonary macrophage transplantation (PMT) had an improved therapeutic effect on mice with ALI. Mortality, lung inflammation, and tissue injury decreased in mice transplanted with IL-4-secreting macrophages...
We investigated the response of purified and cloned human thymic epithelial cells (TEC) to IL-1, IL-4, and IFN-gamma stimulation in vitro. IL-1 alpha strongly up-regulated the production of granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), IL-6, and IL-8, as measured by...
of NO and cytokines (TNF-alpha, IL-1, IL-6) secreted from macrophage after LPS stimulation, reduce the concentration of serum IgE in an asthma animal model induced by ovalbumin, and suppress production of IL-4, IL-5, IL-10, ... EK Lee,YN Park,SG Kim,... 被引量: 0发表: 2013年...
We show that in response to IL-4 and IL-13, Lyz2(lo)IL-4Rα(+) macrophages differentiate into an arginase 1-expressing alternatively-activated macrophage (AAM) population, which slows the development of lethal fibrosis in schistosomiasis. In contrast, we identified Lyz2(hi)IL-4Rα(+) ...