7. Du Plessis, N., Kleynhans, L., Thiart, L., Van Helden, P.D., Brombacher, F., Horsnell, W.G.C., and Walzl, G. (2013). Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol. 6, 931–941. https://doi.org/10.1038/mi.201...
摘要 Macrophages are a highly adaptive population of innate immune cells. Polarization withIFNγandLPSinto the “classically activated” M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as Mycobacterium tuberculosis. By contrast, “alternatively activate...
摘要 Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to contribute to age-related diseases. Although aging-associated immune dysfunction, or immunosenescence, is known to contribute to this process, the underlying mechanism remains elusive. Here, we report that...
Furthermore, macrophage subsets can be very heterogenous (linked to their differing cellular origins) and the relative role of these subsets in the context of M(IL activation to helminth infection is unknown. An article by Rolot et al. in this issue of the European Journal of Immunology [Eur...
Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1. ...
(IL-4Ra)-dependent macrophage activation con- trolled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects. We identified Relm-a as one important player in the ...
and lung metastases during malignant progression. We further show that tumor-associated macrophage (TAM)-supplied cathepsins B and S are critical for promoting pancreatic tumor growth, angiogenesis, and invasion in vivo, and markedly enhance the invasiveness of cancer cells in culture. Finally, we ...
Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1. ...
IL-4, through its activation of STAT6, upregulates GATA3 expression and also suppresses TH1 and TH17 cell responses, partly through the upregulation of growth factor independent 1(GFI1), a transcriptional repressor of IFN&gammal and IL-17 production. IL-4 induces macrophage activation and TSLP...
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity Immunity (2023) Z. Zhou et al. Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging Immunity (2024) Z. Czimmerer et al. The Tr...