7. Du Plessis, N., Kleynhans, L., Thiart, L., Van Helden, P.D., Brombacher, F., Horsnell, W.G.C., and Walzl, G. (2013). Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol. 6, 931–941. https://doi.org/10.1038/mi.201...
摘要 Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the “classically activated” M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as Mycobacterium tuberculosis. By contrast, “alternatively ...
Similar differences were recorded in the response profiles to IL-4 and IL-13 by monocytes and monocytes cultured for 7 days in macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage CSF (GM-CSF) (monocyte-derived macrophages, MDMac). MDMac have reduced gamma(c) mRNA levels ...
摘要 Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to contribute to age-related diseases. Although aging-associated immune dysfunction, or immunosenescence, is known to contribute to this process, the underlying mechanism remains elusive. Here, we report that...
A seminal study of macrophage gene expression patterns upon exposure to a diverse range of stimuli in vitro revealed that their transcriptomes exist along a spectrum of states; the opposite poles were represented by those enacted by proinflammatory lipopolysaccharide (LPS) and interferon-gamma (IFNγ)...
Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1. ...
Nattectin induces M1 activation of macrophages. The influx of macrophages induced by Nattectin is totally dependent on IL-4 and IFN-γ. IL-4 is able to work as a coadjuvant with IFN-γ and IL-12 in the macrophage M1 polarization induced by Nattectin....
IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.靶...
IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure...
IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; B-cell stimulatory factor 1; BSF-1.靶...