9. Gunasinghe, N. P. A. D., Wells, A., Thompson, E. W. & Hugo, H. J. Mesenchymal–epithelial transition (MET) as a mechanism for metastatic coloni- sation in breast cancer. Cancer Metastasis Rev. 31, 469...
Conclusion: Intermittent hypoxia acts as a potent proinflammatory stimulus, resulting in IL-6 induction and M1 macrophage polarization. Increased IL-6 expression may be due to both induction of antioxidant response element and nuclear factor kappa B as well as inhibition of miR-365 expression. ...
Contents lists available at ScienceDirectCancer Lettersjournal homepage: www.elsevier.com/locate/canletOriginal ArticlesIL-6 induced M1 type macrophage polarization increases radiosensitivity inHPV positive head and neck cancerXiaohang Chen a,b , Enhui Fu a , Huihuang Lou a , Xionghui Mao c , Bing...
The fact that expansion of HcPCs is dependent on IL-6 [90], that IL-6 promotes M2 macrophage polarization [64] and that growth of HCC seems to be promoted by M2 macrophages [107] suggest that HCC patients might benefit from an IL-6 directed therapy. Beside its direct effect on tumor ...
本研究结果显示,宫颈癌细胞上清可抑制巨噬细胞M1型细胞因子如IL-1β及IL-6的表达,而促进M2型细胞因子如IL-10和CCL22的表达,从而使巨噬细胞呈现肿瘤支持性的M2型分泌谱。这与之前在肿瘤组织中观察到的现象一致。而经LPS作用后,宫颈癌细胞上清...
Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), enhance macrophage activation and antigen presentation, inducing osteoclast formation and regulating inflammation through different mechanisms17,18. IL-6 is assumed to be the “classic” pro-inflammatory ...
We found that IL-6 expression in TAMs gradually increased with tumor progression and played an important role in macrophage-mediated activation of EMT in lung adenocarcinoma. It was able to promote the progression, invasion, and metastasis of lung adenocarcinoma cells in vivo and in vitro. IL-6...
M1 type macrophages can be induced by LPS or IFN-γ [2, 3] , IL-4 and IL-13 can induce macrophage to M2 polarization [2] . M1 macrophages mainly produce inflammatory cytokines, like TNF-α and IL-12 [4] , playing an important role in removalling of bacteria, viruses and fungi...
14e–g). Interestingly, FoxM1 was recently reported to promote liver regeneration through a vagus-macrophage-hepatocyte link44. Quantitative RT-PCR analysis shown that Barx2, Elf3, Mxd3 and FoxM1 in hepatocytes were dramatically increased after cultured with IL6-HCM for 14 days and in IL6-...
( P <0.05).As compared with those in group B, the expression levels of M2 macrophage related cytokines-CCL22 and IL-10 mRNA and protein were significantly up-regulated in group C ( P <0.05),but the expression levels of M1 macrophage related cytokines-IL-12, TNF-α lpha mRNA and ...