内容提示: ·论 著·IL-6对 M1 型巨噬细胞向肿瘤相关 M2型巨噬细胞转化过程的诱导作用王青山 倪虹 魏晓丽 李玉皓 向荣 王悦【摘要】 目的 共培养小鼠 M1型巨噬细胞 RAW264.7与乳腺癌细胞 4T1, 观察白介素 6(IL-6)在 M1型巨噬细胞向肿瘤相关M2型巨噬细胞转化过程中的作用。 方法 实验共分为以下 3 组...
9. Gunasinghe, N. P. A. D., Wells, A., Thompson, E. W. & Hugo, H. J. Mesenchymal–epithelial transition (MET) as a mechanism for metastatic coloni- sation in breast cancer. Cancer Metastasis Rev. 31, 469...
Conclusion: Intermittent hypoxia acts as a potent proinflammatory stimulus, resulting in IL-6 induction and M1 macrophage polarization. Increased IL-6 expression may be due to both induction of antioxidant response element and nuclear factor kappa B as well as inhibition of miR-365 expression. ...
Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), enhance macrophage activation and antigen presentation, inducing osteoclast formation and regulating inflammation through different mechanisms17,18. IL-6 is assumed to be the “classic” pro-inflammatory ...
The supernatant of STAT5A1*6-transduced cells contained sufficient concentrations of IL-6 to induce macrophage differentiation of parental M1 cells, and STAT3 was phosphorylated on their tyrosine residues in these cells. Treatment of the cells with anti-IL-6 blocking Abs profoundly inhibited the ...
细胞诱导分化macrophages机制removalling 目录 缩略语表...1 英文摘要...
14e–g). Interestingly, FoxM1 was recently reported to promote liver regeneration through a vagus-macrophage-hepatocyte link44. Quantitative RT-PCR analysis shown that Barx2, Elf3, Mxd3 and FoxM1 in hepatocytes were dramatically increased after cultured with IL6-HCM for 14 days and in IL6-...
In conclusion, IL-6 cooperated with M-CSF could induce CD14+monocytes differentiate to M2-like(IL-10 high TGF-β high IL-12 low ) macrophages by activating STAT3 signal pathway.[Key words] IL-6; STAT3; Macrophage; M2 polarization巨噬细胞是免疫系统的主要组成部分,其发挥重要的防御功能。对巨...
We found that IL-6 expression in TAMs gradually increased with tumor progression and played an important role in macrophage-mediated activation of EMT in lung adenocarcinoma. It was able to promote the progression, invasion, and metastasis of lung adenocarcinoma cells in vivo and in vitro. IL-6...
( P <0.05).As compared with those in group B, the expression levels of M2 macrophage related cytokines-CCL22 and IL-10 mRNA and protein were significantly up-regulated in group C ( P <0.05),but the expression levels of M1 macrophage related cytokines-IL-12, TNF-α lpha mRNA and ...