The inhibitory effect of IL-10 was restricted to treatment 48 h after stimulation with GM-CSF. Addition of IL-10 after that time induced neither apoptosis nor a decrease in expression of bcl-2, bcl-x(L), and mcl-1 mRNA. IL-10, however, inhibited LPS-induced TNF-alpha production even ...
nature publishing group ARTICLES IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis B Li, R Alli, P Vogel and TL Geiger Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this...
Data are normalized to Tbp expression and displayed as mean ± SEM with n = 8 per cell type. MØ, macrophage; mono, monocyte. (D) Correlation between IL10 expression and various myeloid-associated genes in human breast cancer samples from the TCGA data set (n = 1,161). (E) Detection...
CD40 costimulatory receptors on macrophages promote the effect of IL-12 and IFN and activate T-cell immunity. While IL-6 promotes the transition of macrophages to a pro-tumor phenotype and promotes the secretion of inflammatory suppressors such as IL-10 and TGF-β. However, Yang et al. found...
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Macrophages undergoing EIMP are competent efferocytes and producers of TGFβ and IL-10 in vitro We reasoned that EIMP would expand the pool of macrophages capable of clearing ACs and producing pro-resolving molecules. We therefore tested whether macrophages that had undergone EIMP were adequate ...
In vitro, SM934 enhanced IL-10 production from primary macrophages stimulated with IFN-γ.The results of this study demonstrated that artemisinin analogue SM934 had therapeutic effects on lupus-prone female NZB/W F(1) mice by inhibiting the pathogenic helper T cell development and enhancing anti-...
Intrinsic ADE, which results from signaling through ligated FcRs, is postulated to suppress antiviral responses, selectively enhance cytokine production (particularly IL-10) and enhance virus replication [19]. Additional or alternative mechanisms may also be involved [20]. Infection of monocytes by ...
Targeting tumor-infiltrating macrophages limits progression and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease-ac
then IL-10 signaling and finally the induction of oxidative phosphorylation by IL-4/Polyamine signaling. Importantly, loss-of-function of glucocorticoid and IL-10 signaling shows that each step of the sequence is independently activated. Lastly, we show that IL-10 and IL-4 signaling act synergist...