The SLIT2 receptor ROBO2 plays a key role in the formation of the ureteric bud, and its inactivation in mice leads to supernumerary ureteric bud development, lack of ureter remodeling, and improper insertion of the ureters into the bladder. Recently, two heterozygous ROBO2 missense mutations ...
nature publishing group ARTICLES IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis B Li, R Alli, P Vogel and TL Geiger Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this...
Total RNA was obtained from mouse macrophages J774 A.1 before or after stimulation with IL-10 (20 ng/ml). Poly(A)+RNA was isolated in both cases in order to obtain driver and tester mRNA. Subtraction suppression hybridization was performed using the PCR-select cDNA subtraction procedure...
Surface IL-10 is not unique to the 12j macrophage hybrid and may correlate with the absence of bactericidal activity in other macrophages. For instance, nonlistericidal resident and thioglycolate-elicited peritoneal exudate cells have 24 to 72% IL-10-positive macrophages. In contrast listericidal ...
IL-10, in addition to being a cytokine synthesis-inhibitory factor, is a cytokine that exerts multiple effects on various cell types. Recombinant human migration inhibitory factor (MIF) inhibits the migration of human monocytes as well as that of guinea pig and murine macrophages. In addition, ...
PNAS Plus: Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells Cd47-Sirpαinteraction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Bian Z,Shi L,Guo YL,et al. Proceedings of ... Z Bian,L Shi,YL...
(Vega MA et al, 2020) and v) upregulated genes of M-CSF-derived macrophages stimulated with 5-HT (serotonin) (Nieto C et al, 2020; Domínguez-Soto Á et al, 2017) 上调基因标注注释细胞,发现M1 CXCL5与体外GM-CSF诱导巨噬细胞相似性较大,而M1 ACOD1与M-CSF和GM-CSF+LPS诱导的巨噬细胞...
Cerebral regu- latory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10. Eur J Immunol 2015; 45: 180-191.L. Xie, G. R. Choudhury, A. Winters, S.-H. Yang, and K. Jin, "Cerebral regulatory T cells restrain microglia/macrophage- mediated inflammatory responses ...
Conversely, significantly increased IL-10 and significantly decreased IL-12 expression were observed in mouse peritoneal macrophages isolated from EL knockout mice. Finally we show that the catalytic activity is required for EL to modulate the balance of macrophage IL-10 and IL-12 production. These...
suggests a critical self-recognition mechanism, in which CD47 is the ubiquitous marker of self, and its interaction with macrophage signal regulatory protein α (SIRPα) triggers inhibitory signaling through SIRPα cytoplasmic immunoreceptor tyrosine-based inhibition motifs and tyrosine phosphatase SHP-1/...