Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse. Int Immunopharmacol. 2011;11(7):862-872.Kim SW, Kim JS, Papadopoulos J, Choi HJ, He J, Maya M, et al. Consistent interactions between tumor...
Keenan JA, Chen TT, Chadwell NL, Torry DS and Caudle MR (1994) Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-conditioned media of women with endometriosis. Am J Reprod Immunol 32,180-183....
underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophagesubpopulations as key mediators of HNSC radiosensitivity linked to HPV status. We collected forty-one clinicalHNSC specimens and determined HPV status and radiosensitivity of each sample. We investigated cy...
The survival rate was improved by the treatment of IL-6-deficient mice with a NO production-specific inhibitor. Our data revealed that IL-6 regulates the excessive release of NO through IL-1β inhibition and determines the establishment of an M2 macrophage profile within infected heart tissue. ...
Macrophage recruitment to adipose tissue is a hallmark of obesity and can contribute to insulin resistance. Kraakman etal. show that IL-6 trans-signaling is responsible for macrophage recruitment to adipose tissue in obesity, a process that can be blocked by treatment with a soluble gp130Fc ...
To examine whether Nrf2 directly binds to the M1-induced genes, we performed Nrf2 ChIP-seq analysis. In the M1-induced gene loci, Nrf2 binding was observed in the upstream regions of theIL6andIL1bgenes (Fig. 2a,b). Nrf2 binding was also detected in the downstream region of theIL1agene...
3b). Moreover, the LPS-induced levels of pro-inflammatory genes and factors such as IL-6, tumor necrosis factor (TNF), nitric oxide (NO), and reactive oxygen species (ROS) were even increased in the absence of Acly (Fig. 3c, d). Likewise, we detected increased inflammatory gene ...
Intermittent hypoxia results in significant induction of interleukin (IL)-6 expression in both hepatocytes and macrophages. The increase in IL-6 expression was independent of hypoxia inducible factor 1 induction but appeared to be in part related to antioxidant response element and nuclear factor kappa...
MIFandIL6levelsinpatientswithactiveAOSDweresignificantlyhigherthanthoseinstablediseaseandhealthycontrols(P<0.05).MIFlevelswere positivelycorrelatedwiththewhitecellcount(WBC),yetshowednocorrelationwithlevelsofIL6,erythrocytesedimentationrate(ESR),Creactive protein(CRP),plateletcount(PLT)andserumferritin(SF)inpatientswit...
cytokines such as interleukin-1 (IL-1), IL-6, IL-12, IL-23 and TNF-±, and 2) Alternatively activated or M2 macrophages, which are anti-inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL-4 and IL-13 and produce anti-inflammatory cytokines such as IL-10 and ...