NanoGenerator® Systems LipidFlex™ T Cell Kit Lipid nanoparticles for precision medicine therapy study Learn More High Performance & Efficiency Tunable size (40-500nm) Low PDI High encapsulation efficiency Open Platform Microfludic chips Reagents ...
1.Liposome and nanoparticles 1.1 liposome 简介:Liposome是由一个或多个磷脂双层组成的小球形结构,与细胞膜结构非常相似。它们形成了一个能够携带水溶液的内部腔室。 脂质体形成:这个过程始于将中性脂质溶解在氯仿等有机溶剂中。然后在加热下蒸发溶剂,留下干燥的脂质薄膜。向这层干燥的脂质薄膜中加入缓冲液,导致脂质...
Lipid nanoparticles possess a solid particle matrix ideal for the incorporation of lipophilic UV radiation (UVR) filters. Incorporation of the UVR filters into the nanoparticles increases their UVR protective effect compared with oil-in-water emulsions. Due to the solid state of the particle matrix,...
题目:GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy 译名:GalNAc-Lipid纳米粒可实现非LDLR依赖的CRISPR碱基编辑疗法的肝脏递送 期刊:Nature Communications IF:17.694 发表时间:2023....
Lipid nanoparticles (LNPs) for RNA and DNA delivery have attracted considerable attention for their ability to treat a broad range of diseases and to vectorize mRNA for COVID vaccines. LNPs are produced by mixing biomolecules and lipids, which self-assemble to form the desired structure. In this...
Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J. Control. Release 325, 370–379 (2020). CAS Google Scholar Kormann, M. S. et al. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nat. ...
脂质体与纳米颗粒相互作用的探讨 脂质体作为一种由磷脂双层构成的小球形结构，与细胞膜结构极为相似，具备携带水溶液内部腔室的特性。脂质体形成过程始于中性脂质溶解于氯仿等有机溶剂中，加热蒸发溶剂后，通过加入缓冲液促使脂质膨胀，形成囊泡。囊泡类型包括多层囊泡（MLV）、大单层囊泡（LUV）和小单层...
脂质体(Liposomes)、脂质纳米颗粒 (LNP,Lipid Nanoparticles) 和其他基于脂质的制剂已被临床证明可提高多种活性药物成分 (API,,active pharmaceutical ingredients) 的治疗指数。脂质是一类两亲性(amphipathic)生物分子,当掺入药物产品中时,它们表现出理想的安全性和药代动力学特征。最近,由于将 LNP 纳入基于信使 RNA ...
The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy 原文链接:https://doi.org/10.1021/acs.bioconjchem.0c00366 Abstract: -通过基因沉默、蛋白表达或基因修正,基因疗法在治疗几乎任何疾病方面都具有巨大的潜力。为了有效地将核酸有效载荷传递到目标组织,遗传物质需要与传递平台相结合。脂质纳米颗粒(LNPs...
根据脂质纳米粒结构和载药机制的不同,可将其分为:固体脂质纳米粒、纳米结构脂质载体、脂质-药物共轭物、聚合物脂质杂化纳米粒。 固体脂质纳米粒(Solid Lipid Nanoparticles,SLN)由固态天然或合成的脂质包载药物形成固体胶质给药系统,是一代脂质纳米粒。固体脂质纳米粒由O/W乳剂衍生而来,以脂质基质替换乳剂的液态脂质...