The extent and ability of nanoparticles to penetrate into the underlying viable tissue is still the subject of debate although recent studies have identified the follicular route as the most likely route of entry; this influences the potential applications of these dosage forms as a drug delivery ...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We optimized the composition, molar ratios ...
Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery.Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine, nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid ...
To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
lipid nanoparticle‐based systems for biomacromolecule therapeutic deliverynovel formulation development for NDEssolid lipid nanoparticles (SLNs) ‐ new class of drug carrierbovine serum albumin (BSA) crystalsadministration, delivery and targetingbiopharmaceutical applications...
Albertsen Hald C, Kulkarni JA, Witzigmann D, Lind M, Petersson K, Simonsen JB. “The role of lipid components in lipid nanoparticles for vaccines and gene therapy.” Adv Drug Deliv Rev 188 (2022): 114416. https://doi.org/10.1016/j.addr.2022.114416 ...
Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delivery – a review of state of art and recent advances Intl J of Nanoparticles. 2010;3(1):32-52.Thiruganesh, R. ; Devi, S. K. U.: Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delive...
Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both...
NLC: nanostructured lipid carriers; LEU: leuprolide; HIP: hydrophobic ion pair; SLN: solid lipid nanoparticles. 2.3.2 Particle size It was shown that the permeation rate of self-emulsifying drug delivery systems across mucus was influenced by the size of the nanocarriers with an increased transport...
Active targeting approaches involve modification of the surface of mRNA–LNPs for their delivery to a specific cell type; improvements in the ability to target nanoparticles to specific cell types is key for expanding their applications in clinical oncology.This...