Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology 2011; 5(4):636-649.Gao Y,Yang R,Zhang Z. Solid lipid nanoparticles reduce systemic toxicity of docetaxel:performance and mechanism in animal[J].Nanotoxicology,2011,(04):636-649....
Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generated by LNP-encapsula...
& Peer, D. The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials 31, 6867–6875 (2010). CAS Google Scholar Dokka, S., Toledo, D., Shi, X., Castranova, V. & Rojanasakul, Y. Oxygen radical-mediated ...
Collectively, the observed variation in lysosomal colocalization among nanoparticle formulations that employ the same endocytic mechanism could not be correlated to the physical-chemical properties of nanoparticles that control TE such as size, surface charge, and nanostructure. This observation suggests that...
Several obstacles frequently encountered with anticancer drugs, such as normal tissue toxicity, stability, poor specificity and a high incidence of drug resistant tumor cells, are overcome by delivering them using Lipid Nanoparticles (LNs). LNs include Solid Lipid Nanoparticles (SLNs) and Nanostructured...
Lipid nanoparticles (LNPs) have shown great promise for mRNA delivery, but challenges such as toxicity and immunogenicity still remain to be addressed. In this study, we aimed to compare the performance of polyplex nanomicelles, our original cationic polymer-based carrier, and LNPs in various ...
Lipid nanoparticles (LNPs), possessing excellent biocompatibility and low toxicity, are a clinically approved small interfering RNA (siRNA) delivery system for liver diseases, so we decided to use this technology to deliver fluorescent probes for detection of ROS in hepatocellular carcinoma (HCC). HCC...
ApoA-1, a natural ligand of scavenger receptor class B type 1 (SR-B1), is commonly enriched in protein corona of lipid nanoparticles and plays crucial roles in modulating nanoparticle-cell interactions. High-density lipoprotein (HDL) is a natural nanoparticle containing ApoA-1, and it mainly tr...
Given the ability of ionizable lipids to enhance endosomal escape in a context of lipid nanoparticles (LNP), here, we provide the first report on the effect of an ionizable lipid conjugate on siRNA endosomal escape, tissue distribution, efficacy, and toxicity in vivo. After developing a ...
Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. This paper revie...