TECHNOLOGY Nanoparticle Drug Delivery Learn about nanoparticle engineering and how DIANT’s technologies can streamline the research and manufacture of LNPs and other biotargeted nanomedicines and nanoparticles. USE CASES Industrial Applications Learn how customers seeking nanoparticle technology for ...
Long experience with versatile API and formulations: Lipid Nanoparticles (LNPs), Liposomal Complexes, PEGylated Molecules, Suspensions, Small Molecules, Oligonucleotides (mRNA, siRNA, RNAi, saRNA, DNA, Duplexes), Proteins, Aseptic Preparations, Proteins Advanced analytical testing equipment and expertise. ...
In genomic medicines, the drug delivery challenge is getting the active pharmaceutical ingredient (API) into the target cells at the disease site. Lipid nanoparticles (LNPs) are an elegant solution for DNA or RNA delivery as they protect the cargo from degradation and mediate a safe and targeted...
在与生物液体接触时,例如在物理化学表征或体外和体内研究中,LNPs吸附环境中存在的生物分子,使LNPs具有新的生物特性。生物分子电晕可以改变LNP的特性,从而导致颗粒团聚、LNP含量提前释放或脂质分解。因此,LNPs的物理化学特性和体外测试必须在模拟生理环境的生物成分存在的情况下进行 2)第二段: -蛋白冠也会改变纳米颗粒的...
Lipid nanoparticles (LNPs) for RNA and DNA delivery have attracted considerable attention for their ability to treat a broad range of diseases and to vectorize mRNA for COVID vaccines. LNPs are produced by mixing biomolecules and lipids, which self-assemble to form the desired structure. In this...
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs, including payload distribution and capacity, which are critical to understanding structure-property-function relationships for further carrier ...
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
The development of lipid nanoparticles (LNPs) as gene vehicles is revolutionary progress that has contributed the clinical application of nucleic acid therapeutics. LNPs have the capability to entrap and transport various genetic materials such as small interfering RNA, mRNA, DNA, and gene editing ...
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, the ability of LNPs to effectively encapsulate large-size DNA molecules remains elusive. This is a
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We optimized the composition, molar ratios ...