To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
Sequences for LNP barcodes and templates for mRNA. About this article Cite this article Kim, H., Zenhausern, R., Gentry, K.et al.Lipid nanoparticle-mediated mRNA delivery to CD34+cells in rhesus monkeys.Nat Biotechnol(2024). https://doi.org/10.1038/s41587-024-02470-2 ...
Nevertheless, the inherent structural instability of mRNA requires the development of effective delivery systems. Lipid nanoparticles (LNPs) have emerged as significant candidates for mRNA delivery in cancer immunotherapy, providing both protection to the mRNA and enhanced intracellular delivery efficiency. ...
内容提示: Chemistry of Lipid Nanoparticles for RNA DeliveryPublished as part of the Accounts of Chemical Research special issue “mRNA Therapeutics”.Yulia Eygeris, ∥ Mohit Gupta, ∥ Jeonghwan Kim, and Gaurav Sahay*Cite This: https://doi.org/10.1021/acs.accounts.1c00544 Read OnlineACCESS...
Many materials have been developed that can be used for mRNA delivery, and notably, lipid nanoparticles are excellent nanodrug carriers for mRNA delivery during cancer im- munotherapy, which is a hot topic in tumor therapy at present [23]. A number of lipid nanoparticle–mRNA formulations for ...
Middle: EpCAM-CD3-hFc mRNA-LNP-treated T cells significantly decrease tumor growth. Right: Tumor size and weight are significantly decreased with EpCAM-CD3-hFc mRNA-LNP-treated T cells. See all the data in the paper “mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific ...
To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA ...
It was a long road to optimizing lipid nanoparticle formulations for nucleic acid delivery. To achieve clinical efficacy, every aspect of the lipid nanoparticle formulation had to be optimized, and more than 300 ionizable lipids had to be screened. Furthermore, all key steps of the lipid ...
2. The lipid nanoparticle of claim 1, wherein the lipid nanoparticle has a mean diameter from about 50 nm to about 100 nm. 3. A pharmaceutical composition comprising (a) at least one lipid nanoparticle comprising a modified mRNA comprising any one of SEQ ID NOs: 1 or 3-5, encoding a ...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We