通过CRISPR基因编辑技术,构建一个基因敲入小鼠模型一般需要6-9个月。 通过ES细胞打靶技术,构建一个基因敲入小鼠模型一般需要9-12个月。 您可以联系我们的技术顾问,为您设计并定制您的基因敲入小鼠模型。 南模生物拥有逾6000种基因修饰小鼠模型,也许您感兴趣的品系就在其中,点击查看。 常规基因敲入 外源基因共...
A knock-in mouse into which a mutant amyloid precursor protein (mutant APP) gene described in (a) or (b), below, has been introduced, said mouse being homozygous for the mutant APP gene. (a) A mutant APP gene that codes a mutant murine amyloid-尾 protein and comprises the amino acid...
The present invention addresses the problem of providing a knock-in mouse that develops Osaka-mutation-mediated Alzheimer's disease through gene expression in normal physiological ranges. The problem is solved by a knock-in mouse as described below. A knock-in mouse into which a mutant amyloid pr...
■ Cre Mouse Lines ■ Immunodeficient Mice ■ Rare Disease Models Custom Cell Line Models ● Induced Pluripotent Stem Cells (iPSC)● Knockin Cell Lines● Knockout Cell Lines● Point Mutation Cell Lines● Overexpression Cell Lines● Lentivirus Packaging ...
A tissue specific Knock-In mouse model developed by Creative Animodel, helps to insert new gene at a particular organ of the animal body using vector design and ES cell targeting technique.
Knock-in mouse for modelling blockade of human TNF
We have generated congenic C57BL/6 and CBA strains for the HdhQ150 knock-in mouse model of HD so that homozygotes can be analysed on an F1 hybrid background. Although a significant impairment in grip strength could be detected from a very early age, the performance of these mice in the ...
An autosomal dominant missense mutation in αB-crystallin (αB-R120G) causes cataracts and desmin-related myopathy, but the underlying mechanisms are unknown. Here, we report the development of an αB-R120G crystallin knock-in mouse model of these disorders. Knock-in αB-R120G mice were gene...
P.2.028 Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain We used a particle-based Monte Carlo simulation to dissect the regulatory mechanism of molecular translocation of CaMKII, a key regulator of neuronal synap... J M.,Orejarena,and,....
Nkx2.2:Cre Knock-In Mouse Line: A Novel Tool for Pancreas- and CNS-Specific Gene Deletion Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis 51, 844-851.Balderes DA, Magnuson MA, Sussel L... Balderes,Dina,A.,... - 《Genesis the ...