基因敲入(Knock-in)是在目的基因位置引进特定的突变或外源基因,比如在目的基因引入点突变(模拟人类遗传疾病模型),或将报告基因(如EGFP、RFP、mCherry、YFP、LacZ、Luciferase等)或需要表达的功能性cDNA(如Cre、Dre等)通过同源重组的方式引入目的基因的特定位点,从而使报告基因或其他cDNA的表达与目标基因的表达一...
A knock-in mouse into which a mutant amyloid precursor protein (mutant APP) gene described in (a) or (b), below, has been introduced, said mouse being homozygous for the mutant APP gene. (a) A mutant APP gene that codes a mutant murine amyloid-尾 protein and comprises the amino acid...
Large Fragment Knock-In Mouse Models Using Recombinase-Mediated Cassette Exchange Knock-in (KI) up to 300 kb | Conditional Knockout (cKO) up to 100 kb Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovatio...
The present invention relates to transgenic animals, particularly a knock-in-mouse, as well as to a targeting vector, which is provided for the generation of an animal such as a knock-in-mouse. The present invention further relates to stem cells, preferably murine embryonic stem cells, containi...
中文名称:基因敲入(KNOCK-IN)小鼠模型 英文名称:KNOCK-IN Mouse Model CAS号: 分子式: 分子量:0 EINECS号: Mol文件:Mol File 基因敲入(KNOCK-IN)小鼠模型供应商 更多 上海赫果生物科技有限公司 联系电话:021-57136670 产品介绍: 中文名称:基因敲入(Knock-in)小鼠模型 电话询单 上海亿言生物科技有限公司 ...
A tissue specific Knock-In mouse model developed by Creative Animodel, helps to insert new gene at a particular organ of the animal body using vector design and ES cell targeting technique.
Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK... T Inoue,F Kobirumaki-Shimozawa,T Kagemoto,... - 《Journal of Molecular & Cellular Cardiology》 被引量: 49发表: 2013年 Depressed Fra...
[3] Wu Y, Liang D, Wang Y, Bai M, Tang W, Bao S, Yan Z, Li D, Li J. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell. 2013 Dec 5;13(6):659-62.[4] Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. Gene conversion tracts ...
In addition, the hCD147KI-NSG mouse model allows further study of SARS-CoV-2 in the immunodeficiency condition which may assist our understanding of this virus in the context of high-risk populations in immunosuppressed states. Our data show (1) the human CD147 protein is expressed in ...
We have generated congenic C57BL/6 and CBA strains for the HdhQ150 knock-in mouse model of HD so that homozygotes can be analysed on an F1 hybrid background. Although a significant impairment in grip strength could be detected from a very early age, the performance of these mice in the ...