A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis. 46:318-323.Means, A.L., Xu, Y., Ray, K.C., and Gu, G. (2008). A CK19(CreERT) knockin mouse line allows for conditional ...
However, the wildly used Ucp1-Cre line was generated by random insertion into the genome and showed ectopic activity in some tissues beyond adipose tissues. Here, we characterized a knockin mouse line Ucp1-iCre generated by targeting IRES-Cre cassette immediately downstream the stop codon of the...
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control of a tissue specific gene promoter. In other words, the Cre mouse model allows tissue specific gene modification based on promoter activation. The LoxP mouse line has two loxP elements flanking the entire or part of the gene of interest, giving the loxP mouse defined gene(s) to be ...
knockdown line knock-for-knock principle Knockin knockin model knock-knee knockout knock-out drops knockout mouse Knoll Knoll, Philipp Knoop Knoop hardness number Knoop hardness test Knoop theory Knoop, Hedwig knot knotless anchor suture Knott technique Knott, Margaret knowledge knowledge base Knowles ...
Twitter Google Share on Facebook (redirected fromKnockin, Shropshire) A type of targeted mutation in which an alteration in gene function is produced, usually a gain of function by adding or substituting genetic material. Example Substitution of a mouse gene sequence for a human sequence ...
Laboratory of Little User Name Demo email demo@institute.edu Mouse Short Name TF2 Date Aug 24, 2006 Mouse Line Description This strain is a cross between TF2 knockout and LacZ transgene This line is Transgene Other (Knockout, knockin, conditional etc.) Transgenes (such as GFP) are randomly...
Mice were bred and maintained at the mouse facility of Korea Advanced Institute of Science and Technology (KAIST) according to the Animal Research Requirements of KAIST. All experimental procedures were conducted in accordance to the guidelines of Animal Research Requirements on the protection of animal...
However, if the mice carry nucleotide insertions and/or deletions (InDels) in other genes, which could have unintentionally occurred during the establishment of the KI mouse line and potentially have larger impact than a point mutation, it would confound phenotyping of the KI mice. In this study...