SIRT1 knock-in miceOvarian reserveCaloric restrictionFOX03amTORPrevious studies have proposed that caloric restriction (CR) regulates many cell functions and prolongs the lifespan of an organism. Our previous studies proposed that CR also prevents follicular activation and preserves the ovarian reserve ...
Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. 来自 Semantic Scholar 喜欢 0 阅读量: 204 作者:W Huang,N Zhao,X Bai,K Karram,J Trotter,S Goebbels,A Scheller,F Kirchhoff ...
Consequently, mice lacking apoE (apoEKO) provided the first practical model of hyperlipidemia and atherosclerosis. In this review, we revisit the primary features of lipoprotein metabolism and atherosclerosis in apoEKO mice and the contributions of human apoE isoforms using the apoE knock-in mice. ...
Foxc2, a member of the winged helix transcription factor family, is essential for eye, calvarial bone, cardiovascular and kidney development in mice. Nevertheless, how Foxc2-expressing cells and their descendent cells contribute to the development of these tissues and organs has not been elucidated...
mice verified that HTT with exon 1 deletion was smaller than full-length HTT but was expressed at the same level and in the same distribution pattern as full-length HTT (Fig.1d). Characterization of homozygous d177 mice revealed that they were indistinguishable from WT mice in development and...
参考文献 [1] Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 2014 Jun 5;157(6):1262-1278.[2] Miura H, Gurumurthy CB, Sato T, Sato M, Ohtsuka M. CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial ...
Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system Pharmacological manipulations of nicotinic transmission have long been the only way to investigate the role of nicotinic acetylcholine receptors (nAChRs) in the brain. More recently, however, the use...
CADM1 Mutation Knock-in Mice As Mice Model of ASD Showing Abnormal Excitatory-Inhibitory Synaptic Balancecore behaviorrepetitive/restrictiveK. KojimaE. JimboT. YamagataM. MomoiT. Mom
Our results suggest that Emx1 is not expressed in every neuron in the developing and adult cerebral cortex. This line of cre mice should contribute to the studies of cortical development and plasticity. 展开 关键词: cerebral cortex hippocampus Cre/loxP transgenic mice Emx1 knock-in reporter mice...
(GOIs) and is readily adapted to generate humanized mouse models – reproducing the human expression patterns in mice.With our project strategies, we have used RMCE-based techniques (with BAC fusion and 3 targeting rounds) to achieve large-fragment knockin (LFKI) humanization and genetic ...