网络释义 1. 铁离子调控序列 CsFtn核苷酸序列中含一环颈结构类似序列,与铁离子调控序列(iron-responsive element)相似。CsFtn多肽序列与其它吸虫铁蛋 … www.chemyq.com|基于 1 个网页
This is a 28-nucleotide 5′-UTR sequence in the ferritin mRNA , it is necessary for iron regulation. IRE sequences in the 3′UTR of the transferrin receptor mRNA protect the mRNA from degradation if the iron level is low. Iron is an essential element for many biological functions but ...
In the hyperferritinemia-cataract syndrome, cataracts are associated with hyperferritinemia without iron overload. TheferritinL iron-responsive element, a stem-loop structure in the 5′-untranslated region of the ferritin messenger RNA (mRNA) normally binds acytoplasmic protein, theiron regulatory prot...
Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close to the cap structure of mRNAs represses translation by precludi... E Paraskeva,NK Gray,B Schl?Ger,... - 《Molecular & Cellular Biology》 被引量: 277发表: 1999年 Multiple determinants within iron...
All rights reserved.Keywords: Iron-regulatory proteins; Iron-responsive element; Ferritin; RNA-binding proteins; Posttranscriptional regulation1. IntroductionIron is an essential nutrient and a potentialtoxin. The cloning of the iron-regulatory proteins(IRPs) and understanding of their interactionwith iron...
iron targets complexes of an mRNA structure, the iron-responsive element (IRE) sequence, and ferritin IRE repressors (iron regulatory proteins 1 and 2)... KJ Hintze,EC Theil - 《Proc Natl Acad Sci U S A》 被引量: 279发表: 2005年 DNA and mRNA elements with complementary responses to he...
We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control ...
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They...
A mutation in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload, Am. J. Hum. Genet., 69: 191-197, 2001.Kato J, Fujikawa K, Kanda M, Fukuda N, Sasaki K, et al. (2001) A mutation in the iron-responsive ele- ment of H ferritin mRNA, causing...
Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regu... Several genes critical to the uptake, sequestration, and utilization of iron are regulated at the post-transcriptional level. The mRNAs encoded ...