Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J Biol Chem 269: 30904 -30910, 1994.Samaniego, F., Chin, J., Iwai, K., Rouault, T. A., and Klausner, R. D., 1994, Molecular...
The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor). Expression of these ...
All rights reserved.Keywords: Iron-regulatory proteins; Iron-responsive element; Ferritin; RNA-binding proteins; Posttranscriptional regulation1. IntroductionIron is an essential nutrient and a potentialtoxin. The cloning of the iron-regulatory proteins(IRPs) and understanding of their interactionwith iron...
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They...
In the hyperferritinemia-cataract syndrome, cataracts are associated with hyperferritinemia without iron overload. TheferritinL iron-responsive element, a stem-loop structure in the 5′-untranslated region of the ferritin messenger RNA (mRNA) normally binds acytoplasmic protein, theiron regulatory prot...
The iron-responsive element-binding protein (IRE-BP) binds to specific RNA stem-loop structures called iron-responsive elements (IREs), which mediate the post-transcriptional regulation of a variety of genes involved in iron metabolism. The IRE-BP is cytosolic aconitase, and a [4Fe-4S] cubane...
In recent reports attention has been drawn to the extensive amino acid homology between pig heart, yeast, and Escherichia coli aconitases (EC 4.2.1.3) and the iron-responsive element binding protein (IRE-BP) of mammalian cells [Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J....
antibodies to the C subunit, RIIalpha/beta subunits, CREB (cAMP-regulatory element binding protein), phospho-CREB, CBP (CREB binding protein), and Sgk... IJ Gonzalez-Robayna,TN Alliston,B Patricia,... - 《Molecular Endocrinology》 被引量: 223发表: 1999年 Extraction of transcription regulatory...
2+ Sensing by Iron-responsive Messenger RNA∙Repressor Complexes Weakens Binding.]]>doi:10.1074/jbc.M109.041061Fe2+ is now shown to weaken binding between ferritin and mitochondrial aconitase messenger RNA noncoding regulatory structures ((iron-responsive element) (IRE)-RNAs) and the regulatory ...
Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5'-untranslated region Iron-responsive elements (IREs) are cis-acting mRNA stem-loop structures that specifically bind cytoplasmic iron regulatory proteins (IRPs). IRP-IRE intera... SA Kohler,BR...