Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J Biol Chem 269: 30904 -30910, 1994.Samaniego, F., Chin, J., Iwai, K., Rouault, T. A., and Klausner, R. D., 1994, Molecular...
The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor). Expression of these ...
Iron-responsive element‒binding proteins (IRP1 and IRP2) bind to the iron-responsive element (IRE) in the untranslated region (UTR) of mRNAs encoding various iron-regulating molecules, thereby regulating their translation. ALAS2: aminolevulinic acid synthase 2; DMT1: divalent metal transporter 1...
Additionally, in support of this connection, suppressing the iron metabolism master regulator IREB2 (iron-responsive element-binding protein 2) decreases sensitivity to ferroptosis14. To better understand these interrelationships, we specify that the IREB2 gene is involved in encoding the iron-responsive...
Divalent metal ion transporter 1 Natural resistance associated macrophage protein 2 Iron responsive element Iron regulatory protein Iron Abbreviations DCT1, divalent cation transporter 1 DMT1, divalent metal ion transporter 1 IRE, iron responsive element IRP, iron regulatory protein ...
内容提示: ReviewIron-regulatory proteins, iron-responsive elements andferritin mRNA translationAndrew M. Thomson a, *, Jack T. Rogers b , Peter J. Leedman aa Laboratory for Cancer Medicine and University Department of Medicine, Royal Perth Hospital, GPO Box X2213, Perth, WA 6001,Australiab ...
Iron regulatory factor (IRF), also called iron responsive element-binding protein (IRE-BP), is a cytoplasmic RNA-binding protein which regulates post-trans... Hirling,Emery-Goodman,Thompson,... - 《Nucleic Acids Research》 被引量: 47发表: 1992年 加载更多来源...
These facts, together with recent evidence that the interconversion process [3Fe-4S]0 + Fe2+ → [4Fe-4S]2+ in the iron-responsive element binding protein (IRE-BP) of eukaryotic cells is controlling protein expression at the level of mRNA (1991, Cell 64, 4771; 1991, Nucleic Acid Res. ...
iron targets complexes of an mRNA structure, the iron-responsive element (IRE) sequence, and ferritin IRE repressors (iron regulatory proteins 1 and 2)... KJ Hintze,EC Theil - 《Proc Natl Acad Sci U S A》 被引量: 279发表: 2005年 DNA and mRNA elements with complementary responses to he...
Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth. Oncotarget 2017, 8, 82231–82243. [Google Scholar] [CrossRef] Horniblow, R.D.; Bedford, M.; Hollingworth, R.; Evans, S.; Sutton, E.; Lal, N.; Beggs, A.; Iqbal, T.H.; ...