6A). These alternative UTRs differ in that one contains an iron-response element (IRE), denoted IRE+, while the other UTR lacks such a motif, denoted IRE−. The IRE+ UTR is primarily expressed in duodenal and kidney epithelium, mediates iron absorption, and is regulated directly by cellul...
In addition to its critical roles in many enzymatic reactions11,12,13, iron directly regulates gene expression to enable the rapid response of cells to environmental cues14,15,16. The most well-characterized iron-regulated genes contain iron-responsive elements (IREs), which are conserved short st...
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network Annu Rev Nutr., 28 (2008), pp. 197-213 CrossrefView in ScopusGoogle Scholar 9 Elin RJ, Wolff SM, Finch CA Effect of induced fever on serum iron and ferritin concentrations in man ...
Results from reporter assay by using a cytomegalovirus enhance/promoter driven luciferase mRNA ligated to the iron response element (IRE) of mACON as a reporter construct demonstrated that modulation of FAC on gene translation of mACON gene is dependent on the IRE. Transient gene expression assays ...
DCT1/DMT1 mRNA levels in the duodenum strongly increase in response to iron depletion. To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types. We found that only the iron responsive element (IRE)...
Uranium is a natural element which is mainly redistributed in the environment due to human activity, including accidents and spillages. Plants may be useful in cleaning up after incidents, although little is yet known about the relationship between metal speciation and plant response. Here, J-Chess...
- 《Biological Trace Element Research》 被引量: 7发表: 2010年 Parenteral iron therapy in children with iron deficiency anemia Objective €" The aim of the study was to determine the efficacy and safety of intravenous iron preparations in a group of children with iron deficiency a... E Manta...
- 《Biological Trace Element Research》 被引量: 11发表: 2001年 Iron intakes and status of 2-year-old children in the Cork BASELINE Birth Cohort Study Young children are at risk of iron deficiency and subsequent anaemia, resulting in long-term consequences for cognitive, motor and behavioural ...
Benthic element cycling, fluxes and transport of solutes across the benthic boundary layer in the Mauritanian oxygen minimum zone, (SFB754) - Cruise No. M1... Oxygen minimum zones (OMZs) that impinge on continental margins favor the release of phosphorus (P) from the sediments to the water ...
Iron is an essential element for plants and microbes. However, in most cultivated soils, the concentration of iron available for these living organisms is ... P Lemanceau,P Bauer,S Kraemer,... - 《Plant & Soil》 被引量: 242发表: 2009年 Rhizosphere interactions: root exudates, microbes, ...