IronHypoxanthine PhosphoribosyltransferaseDNA-Binding ProteinsTrans-ActivatorsPhosphoproteinsTumor Suppressor ProteinsMutationTo better understand cellular responses in human lymphoblastoid cell TK6 after exposure to C-ion (22 keV/μm) and Fe-ion (1000 keV/μm), both protein induction and cell-cycle ...
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair. Highly orchestrated regulatory systems control cellular and systemic iron fluxes ensuring sufficient iron delivery to tar...
International Journal of Molecular Sciences Review Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization Patrick Maier *, Linda Hartmann, Frederik Wenz and Carsten Herskind Received: 29 September 2015; Accepted: 25 December 2015; Published: 14 January ...
Activation of the NLRP3 inflammasome is critical in the inflammatory response to gout. Potassium ion (K+) efflux mediated by the TWIK2 channel is an important upstream mechanism for NLRP3 inflammasome activation... Authors: Dianze Song, Xiaoqin Zhou, Qingqing Yu, Renjie Li, Qian Dai and Mei...
The overall results suggest that both sodium sequestration and potassium ion balancing are mechanisms contributing to salinity tolerance. Using advanced microscopy, we are first to detect chloride and potassium localization in plant cells at the subcellular level using live imaging. 展开 ...
Fig. 3: SOD3 bound T cells and suppressed the IFN-γ response to parasite infection. a SOD3 can bind both T cells and NK cells. Black line indicates the blank control, and the gray line represents omission of the primary antibody as the negative control. The Alexa Fluor™ 488-conjugate...
patterns in order to maintain growth under new conditions. Bacterial as well aseukaryotic cellssuch as yeast possess various response mechanisms to counterbalance fluctuations in growth parameters such as temperature, pH, solute concentration,oxygenation,metal ionconcentration, or high levels of organic ...
In the nucleus, Nrf2 forms heterodimerization with Maf and binds to antioxidant response elements (AREs), and activates downstream genes (such as NQO1, HO-1, FTH1, etc.) that regulate iron and ROS metabolism via MT -1G, and thus inhibits ferroptosis induced by Erastin and sorafenib in HCC ...
Typhimurium (Additional file 6: Table S6B), demonstrating that yqiC contributed to the expression of menD in MK biosynthesis. yqiC is involved in electron ion transfer through the binding of molybdenum iron, iron ions, and iron–sulfur cluster The most significantly enriched GO terms include the...
Lastly, stretch ion channels are protein complexes in the cell membrane that open their central pore in response to externally applied strains (Arnadottir and Chalfie, 2010; Sachs, 2010; Haswell et al., 2011). It is postulated that forces applied to the cell membrane lead to an increase ...