patterns in order to maintain growth under new conditions. Bacterial as well aseukaryotic cellssuch as yeast possess various response mechanisms to counterbalance fluctuations in growth parameters such as temperature, pH, solute concentration,oxygenation,metal ionconcentration, or high levels of organic ...
Stimulating autophagy during periods of starvation is an evo- lutionarily conserved response to stress in eukaryotes. Under starvation conditions, the degradation of proteins and lipids allows the cell to adapt its metabolism and meet its energy needs. The physiological importance of basal autophagy in...
Amino acid limitation activates the GCN2 starvation response and represses mTOR activity, resulting in changes in transporter gene expression12. To assess the extent to which this occurred under screening conditions we used western blotting to assay phosphorylation of mTORC1 and GCN2 targets (Extended...
Interestingly, the 3’-UTR of humanCD133transcripts bears a noncanonical iron-responsive element that may mediate their stabilization after the binding of cytosolic iron-regulatory protein 1, a key controller of iron metabolism that posttranscriptionally regulates the expression of iron metabolism genes. ...
Briefly, 15 days-old flies (supplemented and CTR) were first subjected to starvation for 2 h then transferred to parafilm-sealed vials (ten flies per vial) containing Whatman filter paper discs (diameter 2 cm) soaked with 2.5% sucrose solution and 17.5%, ethanol (Carlo Erba, Milano, ...
It is involved in iron export [110], neural plasticity [111], regulation of synapse formation [112], and also possesses antimicrobial activity [113]. However, sequential APP cleavages give rise to a peptide called β-amyloid (Aβ), which aggregates to form senile plaques in Alzheimer's ...
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer m
Finally, employing the binding phenomena, the difference in metabolic activity in non-cancerous and cancer cells have been well elucidated by the live-cell microscopic investigation in monoculture and co-culture conditions which showed that serum-starvation led to the enhancement of intensity in cancer...
Inside the lysosomes, iron and other chemically reactive metals (e.g. copper, zinc and cobalt) can generate reactive oxygen species through Fenton-type chemical reactions, which can lead to oxidization and destabilization of membrane lipids [192,193]. Interestingly, one of the common pathologies ...
This implies that wall composition and structure are actively modified during biological processes and in response to specific functional requirements. Despite extensive research in the area, our understanding of the regulatory processes controlling active and adaptive modifications of cell wall composition ...