Amino acid limitation activates the GCN2 starvation response and represses mTOR activity, resulting in changes in transporter gene expression12. To assess the extent to which this occurred under screening condi
patterns in order to maintain growth under new conditions. Bacterial as well aseukaryotic cellssuch as yeast possess various response mechanisms to counterbalance fluctuations in growth parameters such as temperature, pH, solute concentration,oxygenation,metal ionconcentration, or high levels of organic ...
Stimulating autophagy during periods of starvation is an evo- lutionarily conserved response to stress in eukaryotes. Under starvation conditions, the degradation of proteins and lipids allows the cell to adapt its metabolism and meet its energy needs. The physiological importance of basal autophagy in...
Plants suffer from abiotic stress due to several soil- and environment-related factors. They need water and essential plant nutrients to carry out their metabolism and survive. Plant genome regulates expression of different sets of genes to ensure availa
to phagocytic invading bacteria [69]. Other favorable conditions for TNT formation are the induction and stimulation of P53 and nanotube formation in hippocampal astrocytes and neurons by serum starvation or hydrogen peroxide [70]. Similarly, hyperglycemic or acidified media and cytokines that stimulate...
pombe promotes both ubiquitination and proteasome cleavage, it would be interesting to investigate a connection with MVB protein sorting pathway. The authors suggest that GQC substrate delivery upon starvation response may be a general pre-autophagic response essential for cell survival or quiescence ...
Caco-2 cells. As transferrin plays the major role in the delivery of iron to cells via endocytosis, it may interfere with hypoxia-induced regulation of CD133 expression. These data justify interest in further studying the CD133/transferrin-iron network and its potential role in endocytosis [152...
In addition, autophagy can also produce cellular energy, especially in starvations conditions [261]. These processes have several regulators, such as insulin/IGF-1, mTOR, AMPK, sestrins and sirtuins, being implicated in aging and disease such cancer [4, 262]. In aging, there is a decrease ...
Transceptors for Micro-Nutrients: Ftr1 for Iron and Zrt1 for Zinc Similar to what happens with macro-nutrients, starvation for micro-nutrients, such as iron and zinc, causes growth arrest in the G1 phase, followed by entry into the stationary phase G0, Frontiers in Pha...
requires O2, the O2supplied by CeO2enhanced the glucose depletion that impeded nutrient supply and starved the tumour cells for a synergistic photodynamic/starvation treatment [108]. Whilst authors claimed that NPs resulted in significant tumour inhibition, this study did not perform any histological ...