Correlated to these results, SBP1 promoter showed enhanced activity in response to sulfur starvation. The sulfur starvation induction of SBP1 was abolished by feeding the plants with glutathione (GSH) and was enhanced when seedlings were treated simultaneously with buthionine sulfoxide, which inhibits ...
Cellulase production by fungi is tightly regulated in response to environmental cues, and understanding this mechanism is a key pre-requisite in the efforts to improve cellulase secretion. Based on UniProt descriptions of secretedCarbohydrateActive enZymes(CAZymes), 13 proteins of the cellulase hyper-pr...
but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12and molecular hallmarks of methionine starvation. Supplementation with vitamin B12increases the efficiency
These transporters are strongly upregulated under conditions of sulfur- starvation (Boer et al., 2003). The identification of D-glucosamine 2-sulfate as a non- transported signaling agonist both for Sul1 and Sul2, clearly indicates that the substrate does not have to be t...
to protect them from ferroptosis. Intensive glycolysis of cancer cells in TME leads to glucose starvation. It dictates ferroptosis resistance by activating the AMPK pathway to improve the MUFAs proportion of cell membrane and inducing over-expression of PDK4 to repress the TCA cycle and activity of...
Plants suffer from abiotic stress due to several soil- and environment-related factors. They need water and essential plant nutrients to carry out their metabolism and survive. Plant genome regulates expression of different sets of genes to ensure availa
Currently three members form the CDGSH iron‑sulfur domain (CISD) protein family, and these are CISD1 (mitoNEET), CISD2 (NAF-1) and CISD3 (Miner2). CISD1 and CISD3 localize to the OMM and mitochondrial matrix, respectively [1]; while CISD2 localizes to both the OMM and ER [[1]...
and continuous efferocytosis by macrophages. The catabolism of phagocytosed apoptotic cells by macrophages leads to an increase in the OCR fueled by FAO. In this context, ETC dysfunction by depletion of Rieske iron-sulfur protein (RISP), an essential subunit of mitochondrial complex III, in LysM...
since it is degraded in the following night to sustain metabolism, energy production and biosynthesis in the absence of photosynthesis. If this night-time carbohydrate supply is reduced—for instance in mutants impaired in starch synthesis—plants grow more slowly and experience acute starvation [4]....
Expression regulation Phosphate limitation induces genes that encode phosphate- liberating enzymes to provide sufficient inorganic phosphate for survival under conditions of phosphate starvation. The E. coli alkaline phosphatase gene phoA is part of the phos- phate regulon, and its express...