To improve our knowledge concerning how cancer cells respond to nutrient withdrawal, the response to glutamine and/or glucose starvation was studied in human in vitro transformed fibroblasts, deeply characterized at the cellular and molecular level. Concomitant starvation of both nutrients led to rapid ...
One of the known cellular responses to glucose starvation is deamination of amino acids, which can then enter the pathways of glucose metabolism as pyruvate, acetyl CoA, or several components of the citric acid cycle. This leads to amino acid starvation that triggers the expression of gcn4. ...
...化过程, 直接或间接性的活化蛋白质, 进而产生一些细胞反应(cellular response)。 www.docin.com|基于5个网页 2. 细胞效应 ...(electrical)刺激在内的多种外界信号发生细胞效应(cellular response);同时,在临床上,心肌细胞对疾病状态下的高血 …
regulated and how theheat shock proteinsfunction. We now know that the so-called heat shock response is really a subset of a more comprehensive cellular stress response. Specific responses occur during ultraviolet light exposure,oxidantinjury, DNA damage, and glucose deprivation. Some of these ...
C. et al. A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy. eLife 5, e09347 (2016). Article PubMed PubMed Central Google Scholar Joyner, R. P. et al. A glucose-starvation response regulates the diffusion of macromolecules. ...
The yeast SNF1 complex is switched on by glucose starvation, and its targets include transcription factors that repress transcription of genes required for catabolism of alternative carbon sources. 展开 被引量: 166 年份: 1999 收藏 引用 批量引用 报错 分享 ...
Senescent cells present high autophagic activity due to the high energetic demand and abundance of aberrant cellular components. Furthermore, it is thought that autophagy activation can initiate cellular senescence [1, 20]. As an example, inactivation of mTORC1 during nutrient starvation initiates ...
Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress....
et al. PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes. J. Cell. Biochem. 120, 343–356 (2019). Article CAS PubMed Google Scholar Lee, W. C., Salido, E. & Yen, P. H. Isolation of a new gene GS2 (DXS1283E) from a CpG...
The deprivation of each nutrient caused a rapid and specific change in c-Myc protein expression (Fig. 1A). In glucose-starved specimens, c-Myc levels were higher than in control cells 6–48 h after starvation and then declined (Fig. 1A), when cells started detaching from the culture dish...