In response to starvation, animals use hormonal cues to mobilize stored resources to provide nutrients to individual cells. Besides whole-body responses to nutrient deprivation, individual cells sense and react to lack of nutrients. At the cellular level, starvation triggers different responses such ...
Genes to cells : devoted to molecular & cellular mechanisms 7 (2):199-215.Morishita M, Morimoto F, Kitamura K, Koga T, Fukui Y, Maekawa H, Yamashita I, Shimoda C (2002) Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating ...
et al. PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes. J. Cell. Biochem. 120, 343–356 (2019). Article CAS PubMed Google Scholar Lee, W. C., Salido, E. & Yen, P. H. Isolation of a new gene GS2 (DXS1283E) from a CpG...
Similarly, depletion of cytosolic nucleotides upon inhibition of de novo pyrimidine synthesis triggers mtDNA-dependent immune responses in wild-type cells. Our results thus identify mtDNA release and innate immune signalling as a metabolic response to cellular pyrimidine deficiencies....
Exposure of cells to conditions such as glucose starvation, inhibition of protein glycosylation, disturbance of Ca2+ homeostasis and oxygen deprivation causes accumulation of unfolded proteins in the ER (ER stress) and results in the activation of a well orchestrated set of pathways during a ...
phosphorylates multiple targets which switch off anabolic pathways and switch on alternative catabolic pathways. The complex is switched on by starvation, and its targets include factors that repress of genes required for of alternative carbon sources. 展开 ...
[110]. During the early stages of starvation, increased phosphorylation of Ser637 due to PKA activity and decreased phosphorylation of Ser616 retain DRP1 in the cytosol, and thus, mitochondria are elongated and spared from autophagic degradation. The resulting tubular mitochondrial network displays an...
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents Article22 June 2015 Introduction During the past decade, significant progress has been accomplished in the developmen...
We have developed a transgenic mouse model to monitor the translational activation of ATF4 in response to cellular stress. By using this mouse model, we were able to detect nutrient starvation response, antivirus response, endoplasmic reticulum (ER) stress response, and oxidative stressand, as ...
Proliferation was reduced with serum starvation (n = 5; P < 0.001, t-test). (l) Relative expression of E6 and E7 in HPVon single clones in 93VU147T (left) and SCC47 (right) under normal growth conditions (+FBS) or serum starvation (-FBS) for 48 hours (n = 3)....