In response to starvation, animals use hormonal cues to mobilize stored resources to provide nutrients to individual cells. Besides whole-body responses to nutrient deprivation, individual cells sense and react to lack of nutrients. At the cellular level, starvation triggers different responses such ...
Dialyzed 3-arm star and hyperbranched PNaA caused an increase in L6 cell viability, challenging the suitability of MTT as cytotoxicity assay for PNaA. Fluorescent confocal microscopy revealed merging of cellular lipids after exposure to PNaA, likely caused by serum starvation. 展开 ...
(2002). Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in ... M Morishita,F Morimoto,K Kitamura,... - 《Genes to Cells》 被引量: 65发表: 2002年 Phosphatidylinositol 3‐phosphate 5‐kinase is required for th...
(Zinke et al., 2002).Drosophila4E-BP (d4E-BP) is abinding proteinthat competes with eIF4E, which is a protein integral toprotein synthesis regulationand translation initiation (Miron et al., 2001). It has been shown that d4E-BP mRNA levels increase upon starvation (Zinke et al., 2002)...
...化过程, 直接或间接性的活化蛋白质, 进而产生一些细胞反应(cellular response)。 www.docin.com|基于5个网页 2. 细胞效应 ...(electrical)刺激在内的多种外界信号发生细胞效应(cellular response);同时,在临床上,心肌细胞对疾病状态下的高血 …
2002. Phosphatidyli- nositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe. Genes Cells 7: 199- 215.Morishita, M., Morimoto, F., Kitamura, K., Koga, T., Fukui, Y., Maekawa, H., Yamashita, I...
358 Actually, it was found earlier that m6A modifications in the 5′ UTR of ATF4 mRNA modulated its alternative translation to mediate re-initiation independent of eIF2α signaling pathway, in response to amino acid starvation, implicating the translation regulation of m6A in integrated stress ...
which in turn reduces mTOR activity and forces downregulation of protein synthesis. Tetraploid yeast cells are sensitive to starvation19and often undergo ploidy reduction13,17,22. Finally, stable tetraploid cells evolved for 1000 generations were smaller than the original cells, although they retained ...
Autophagy is a cellular defense response to stress conditions, such as nutrient starvation. The type III phosphatidylinositol (PtdIns) 3-kinase, whose cata... HX Yuan,RC Russell,KL Guan - 《Autophagy》 被引量: 181发表: 2013年 Membrane-cytoskeleton interactions and the regulation of chemotactic pe...
Stimulating autophagy during periods of starvation is an evo- lutionarily conserved response to stress in eukaryotes. Under starvation conditions, the degradation of proteins and lipids allows the cell to adapt its metabolism and meet its energy needs. The physiological importance of basal autophagy in...