NHE9 Expression in hBMVECs Activates Iron Starvation Response to Promote Iron Uptake Next, we evaluated the hBMVECs response to an increase in NHE9 expression. However, instead of using paracrine signals from iron-deficient astrocytes as the stimulants, we engineered lentiviral-mediated expression of...
starvationironIron deficiency is the most common human nutritional disorder in the world, affecting more than 2 billion individuals; yet, the mechanisms behind many of the manifestations of iron deficiency remain obscure. Iron uptake and utilization has been studied in detail in the budding yeast ...
Apart from anthocyanins, a number of genes that respond to stress were noted. C3H zinc finger; C2H2 zinc finger (STZ), AP2/EREBP; and GRAP; and genes that respond to nutritional status, such as bHLH (cassava4.1_015506m.g), which responds to iron ion starvation; and MYB62, which ...
Our genetic study demonstrates that Grx4-Fra2, but not Fep1 nor Php4, participates not only in iron starvation signaling but also in iron-related aerobic metabolism. Iron-containing Grx4 binds and inactivates the Php4 repressor; upon iron deprivation, the cluster in Grx4 is probably ...
It has been suggested that small-ion permeable pores form on the surface of pyroptotic cells which lead to loss of cellular ionic gradients.69 The resulting osmotic pressure would result in water influx, followed by cell swelling and lysis. Yet it should be noted that the evidence supporting ...
Transcriptional effects on the iron and copper (A) and phosphate uptake and utilization (B) pathways. In both cases, cells were grown on glycerol and shifted to pH 8.0. See main text for details Full size image Phosphate metabolism appears also affected by alkalinization of the medium Fig. ...
Proteomic approaches in Paracoccidioides have been successfully employed by our group in studies focusing on the fungus phase transition [20], as well as the fungal response to iron starvation [21]. Here we employed proteomic strategies to address the question of whether H2O2-treatment of yeast ce...
Iron homeostasis of Shewanella oneidensis, a γ-proteobacterium possessing high iron content, is regulated by a global transcription factor Fur. However, knowledge is incomplete about other biological pathways that respond to changes in iron concentration, as well as details of the responses. In this...
4c), and this was required for salinazid to extend lifespan (Extended Data Fig. 4d). Thus, blocking iron-induced lipid oxidation is important for MUFA-induced longevity (although salinazid could also extend lifespan via other iron-dependent processes or its effect on lipid droplet number). ...
The relA gene had been found to be up-regulated during iron starvation in our previous study5, suggesting that RelA may play an important role in the adaptive response to nutrient starvation in S. suis. Investigation of the mechanism of S. suis adaptation to environments will contribute to ...