In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair. Highly orchestrated regulatory systems control cellular and systemic
Intracellular Iron Metabolism and Cellular Iron HomeostasisIntracellular Iron MetabolismMetal Ion HomeostasisReferencesdoi:10.1002/0470845791.ch7Robert CrichtonJohn Wiley & Sons, Ltd
Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IR...
Biological Process: spleen development; blood vessel development; heme transport; erythrocyte maturation; cellular iron ion homeostasis; in utero embryonic development; multicellular organismal development; multicellular organism growth; regulation of organ growth; mitochondrial transport; embryonic skeletal ...
The microarray analysis revealed increased expression of genes involved in iron homeostasis in the crd1Δ mutant (supplemental Table 1). To confirm the effect of loss of CL on expression of the iron regulon genes, we carried out quantitative PCR analysis of the Aft1-regulated iron uptake genes...
By altering the intake and excretion of iron through FPN and TFRC, ionizing radiation also regulates iron metabolism and homeostasis [51]. The accumulation of labile iron in the cytoplasm produces a Fenton reaction with radiation-induced hydrogen peroxide (Fenton’s reagent), further increasing the ...
IRPs bind to conserved stem-loop structures located within the 5′- or 3′-UTRs of mRNAs that encode proteins for cellular iron transport, storage, and utilization, as well as proteins for energy and oxygen metabolism (63). The first linkage of FeS cluster biogenesis with iron homeostasis in...
The genes with the largest degrees are transcription factors with 4 edges THI2 (thiamine biosynthesis) and 3 edges AFT1 (iron homeostasis), CIN5 (stress response), GAL80 (GAL genes repression), YAP6 (stress response). The PPN and the TRN interface share a percentage of 0.1% edges that ...
In addition, cellular exposure to both NO• (61, 62) and peroxynitrite has been shown to activate mechanisms of iron homeostasis in the direction of iron acquisition. Although their effects have been linked to different mechanisms at the molecular level, based on the present results, we are ...
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nat. Commun. 13, 2483 (2022). Article CAS PubMed PubMed Central Google Scholar César-Razquin, A. et al. A call for systematic research on solute carriers. Cell ...