Altered brain iron homeostasis can contribute to neurodegeneration by interfering with the delivery of the iron needed to support key cellular processes, including mitochondrial respiration, synthesis of myelin and essential neurotransmitters. Intracellular iron homeostasis in mammals is maintained by two homol...
We further describe how these pathways interact with systemic iron homeostasis control through the hepcidin–ferroportin axis to ensure appropriate iron fluxes. This knowledge is key for the identification of novel therapeutic opportunities to prevent diseases of cellular and/or systemic iron mismanagement....
1. Iron Neurotoxicity 1.1. Iron Homeostasis. In mammals, the regulatory mecha- nism for Fe homeostasis is mediated by the iron-regulatory Iron (Fe) is the most important element for almost all types proteins IRP1 and IRP2, which posttranscriptionally mod- of cells, including brain cells. It...
18.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process 机译:2-氧戊二酸依赖性双加氧酶是能量代谢,氧气可用性和铁稳态的传感器:在调节衰老过程中的潜在作用 作者:Salminen Antero;Kauppinen Anu;Ka...
IRP2 functions as an RNA binding protein to regulate the translation and stability of mRNAs that encode proteins required for cellular iron homeostasis. IRP2 thereby increases the size of the available iron pool under iron-limiting conditions. In contrast, under iron-replete conditions, FBXL5, ...
The microarray analysis revealed increased expression of genes involved in iron homeostasis in the crd1Δ mutant (supplemental Table 1). To confirm the effect of loss of CL on expression of the iron regulon genes, we carried out quantitative PCR analysis of the Aft1-regulated iron uptake genes...
90.Integration of DIGE and bioinformatics analyses reveals a role of the antiobesity agent tungstate in redox and energy homeostasis pathways in brown adipose tissue 机译:DIGE和生物信息学分析的整合揭示了抗肥胖剂钨酸盐在棕色脂肪组织的氧化还原和能量稳态途径中的作用 作者:Barcelo-Batllori S;Kalko SG;Est...
is an activator whereas succinate and fumarate are the potent inhibitors of 2-OGDO enzymes. In addition, O2availability and iron redox homeostasis control the activities of 2-OGDO enzymes in tissues. We will briefly elucidate the catalytic mechanisms of 2-OGDO enzymes and then review the potenti...
摘要: Summary This chapter contains sections titled: Intracellular Iron Metabolism Cellular Iron Homeostasis References关键词: intracellular iron metabolism and cellular iron homeostasis intracellular iron metabolism labile iron pool haem biosynthesis iron–sulfur protein biogenesis in eukaryotes cellular iron ...
epidermal growth factor insulin secretion phospholipase D2 glucose homeostasis; 35.Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia 机译:在模拟缺血下酸性预处理可抑制凋亡并增加冠状内皮细胞Bcl-xL的表达 作者:S Kumar;H ...