Altered brain iron homeostasis can contribute to neurodegeneration by interfering with the delivery of the iron needed to support key cellular processes, including mitochondrial respiration, synthesis of myelin and essential neurotransmitters. Intracellular iron homeostasis in mammals is maintained by two homol...
The study of iron homeostasis requires knowledge of the major forms of iron in the body, iron exchange between these components and iron intake and loss. This chapter considers the proteins of iron metabolism, extra-and intra-cellular iron exchange, and the regulation of synthesis and breakdown o...
We further describe how these pathways interact with systemic iron homeostasis control through the hepcidin–ferroportin axis to ensure appropriate iron fluxes. This knowledge is key for the identification of novel therapeutic opportunities to prevent diseases of cellular and/or systemic iron mismanagement....
Adoption of a mesenchymal state is also associated with increased iron uptake, but the relationship between EMT and the key regulators of cellular iron metabolism remains undefined. In this regard, the human adrenal cortical carcinoma SW13 cell line represents an invaluable research model as HDAC ...
Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IR...
Cellular iron homeostasis is coordinately regulated by iron regulatory protein (IRP)3 1 and 2, which posttranscriptionally modulate the expression of critical iron metabolism genes by interacting with conserved cis-regulatory iron responsive elements (IREs) present in the untranslated region (UTR) of ...
18.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process 机译:2-氧戊二酸依赖性双加氧酶是能量代谢,氧气可用性和铁稳态的传感器:在调节衰老过程中的潜在作用 作者:Salminen Antero;Kauppinen Anu;Ka...
90.Integration of DIGE and bioinformatics analyses reveals a role of the antiobesity agent tungstate in redox and energy homeostasis pathways in brown adipose tissue 机译:DIGE和生物信息学分析的整合揭示了抗肥胖剂钨酸盐在棕色脂肪组织的氧化还原和能量稳态途径中的作用 作者:Barcelo-Batllori S;Kalko SG;Est...
is an activator whereas succinate and fumarate are the potent inhibitors of 2-OGDO enzymes. In addition, O2availability and iron redox homeostasis control the activities of 2-OGDO enzymes in tissues. We will briefly elucidate the catalytic mechanisms of 2-OGDO enzymes and then review the potenti...
IRP2 functions as an RNA binding protein to regulate the translation and stability of mRNAs that encode proteins required for cellular iron homeostasis. IRP2 thereby increases the size of the available iron pool under iron-limiting conditions. In contrast, under iron-replete conditions, FBXL5, ...