We investigated changes in cytoplasmic calcium concentration and intracellular calcium localization after shock-wave treatment of suspended cell cultures using flow cytometry and electron microscopy and present evidence for the disturbance of mitochondrial Ca2+ a sequestration and, therefore, for a chemically...
Cell Death and Differentiation OPA1 loss disturbs cellular calcium homeostasis YE Kushnareva et al 356 Figure 2 OPA1 loss leads to mitochondrial fission and cristae abnormalities. (A) Two 2-nm thick slices through EM tomographic volumes of mitochondria in fixed scrambled (control) and OPA1 siRNA...
Ca2+ homeostasis but not signaling defects were also observed in the heterozygous parents of P2. To formally evaluate the impact of the ITPR3 variants on calcium signaling in a model allowing direct comparison in the absence of compensatory mechanisms, we used HEK cells that had been engineered ...
80.Regulation of alpha A- and alpha B-crystallins via phosphorylation in cellular homeostasis 机译:通过细胞稳态中的磷酸化调节αA和αB晶状体蛋白 作者:Thornell Erin;Aquilina Andrew 期刊名称:《Cellular and molecular life sciences: CMLS》 | 2015年第21期 关键词: Chaperones; PTMs; Structure; Prot...
Ayaz and Howlett Biology of Sex Differences (2015) 6:9 DOI 10.1186/s13293-015-0027-9 REVIEW Open Access Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms Omar Ayaz1 and Susan Ellen Howlett1,2* Abstract The incidence of cardiovascular disease rises ...
35 Interestingly, the depletion of intracellular calcium observed on BCL2 inhibition (Figure 4) provides a novel mechanistic explanation for the repressed platelet activation. Several BCL2 proteins, such as BCL-XL, localize to the ER and have been implicated in calcium homeostasis in multiple ways....
slow wave calcium pacemaker cells; 18.The polymine spermine regulates osteogenic differentiation in adipose stem cells 机译:多胺精胺调节脂肪干细胞的成骨分化 作者:GS Tjabringa;B Zandieh-Doulabi;MN Helder;M Knippenberg;PIJM Wuisman;J Klein-Nulend 期刊名称:《Journal of Cellular and Molecular Medi...
Many experiments have been done to clarify the effects of oxygen free radicals on Ca2+ homeostasis in the hearts. A burst of oxygen free radicals occurs im
Calcium is a key mediator controlling essential neuronal functions depending on electrical activity. Altered neuronal calcium homeostasis affects metabolis... Bordji,Karim,Becerril-Ortega,... - 《Journal of Neuroscience》 被引量: 223发表: 2010年 Numb Endocytic Adapter Proteins Regulate the Transport an...
A Novel Germline Mutation, IVS4+1G>A, of the POU1F1 Gene Underlying Combined Pituitary Hormone Deficiency BACKGROUND: POU1F1 is a pituitary transcription factor that plays a pivotal role in pituitary development and expression of the GH, PRL and TSH beta genes... T Snabboon,W Plengpanich,P...