Demonstration of an active Ca 2+ transport system in the mitochondrial inner membrane has led to investigation of the physiological function of this activity. Control of intracellular Ca 2+ ion homeostasis and/or modulation of mitochondrial metabolism may be important consequences of Ca 2+ flux ...
Cell Death and Differentiation OPA1 loss disturbs cellular calcium homeostasis YE Kushnareva et al 356 Figure 2 OPA1 loss leads to mitochondrial fission and cristae abnormalities. (A) Two 2-nm thick slices through EM tomographic volumes of mitochondria in fixed scrambled (control) and OPA1 siRNA...
Elevation of the concentration of free calcium ion in the cytoplasm of cells ([Ca 2+ ] i ) is an early event following the binding of many stimuli to plasma membrane receptors. The free (or ionized) calcium then plays an important role as a coupling factor leading to the activation of ...
The calcium-sensing receptor (CaR) is a G protein-coupled receptor playing key roles in extracellular calcium ion (Ca2+o) homeostasis in parathyroid gland ... T Yamaguchi,I Olozak,N Chattopadhyay,... - 《Biochemical & Biophysical Research Communications》 被引量: 300发表: 1998年 Cellular "sen...
(Long-lasting-type and transient-type calcium channels). Voltage-dependent channels that allow calcium ions to flow into excitable cells, resulting in muscle contraction, neuron excitation, neurotransmitter release or gene regulation. Membrane–organelle-based secretion An unconventional mode of protein sec...
It has multiple functions among which support, weight-bearing and participation in calcium homeostasis are the most important. To understand these properties a certain knowledge of primary bone formation, postnatal growth (modelling) and the continuous renewal of adult bone throughout life (remodelling)...
Several points about the messenger role of Ca2+ are emphasized: small changes in Ca2+ concentration bring about large changes in cell response; the regulation of calcium fluxes across the plasma membrane are critical to proper cell function; and excessive calcium is a cellular toxin. An attempt ...
Calcium handling and downstream signaling pathways Kohn et al. [69] proposed that microgravity induces changes in ion channel activity by altering cell membrane fluidity. This change has been associated with calcium handling abnormalities, contributing to cardiac structural and functional impairments [70]...
During the last 2 years, our laboratory has worked on the elucidation of the molecular basis of capacitative calcium entry (CCE) into cells. Specifically, we tested the hypothesis that CCE channels are formed of subunits encoded in genes related to the Drosophila trp gene. The first step in ...
Calcium signaling from sarcoplasmic reticulum and mitochondria contact sites in acute myocardial infarction Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or complete occlusion of the epicardial coronary arte...