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Fig. 2. PTH-centered model of Calcium homeostasis: PTH regulates the Calcium levels tightly primarily by regulating the tubular reabsorption of Calcium. At the bone level, PTH increases bone turnover and at the kidney level, the conversion from 25-(OH) vitamin D-to 1,25-(OH)2Vi D which...
Hypercalciuria is consequent to a dysregulation of calcium transport in the gut, kidney, or bone, thereby representing a systemic abnormality in calcium homeostasis. The continued excessive urine calcium excretion may result in bone demineralization. To establish the diagnosis of normocalcemic IH in ...
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ER is not only the major site for protein folding, maturation and stabilization, it also has a crucial role in calcium homeostasis.26,27 Therefore, to dissect the role of Ca2 þ in PAC-1-induced ER stress, HeLa cells were stably trans- fected with calcium sensor, D1ER cameleon, to ...
While previous research has highlighted the vital role of calcium in cellular signaling and its involvement with various organelles, there remains a significant gap in our understanding of how calcium impacts peroxisome function, particularly in relation to cellular homeostasis. Thus, this study aimed to...
Significance of Phosphorus Homeostasis Although the above provides some insight into the homeostatic processes associated with Ca2+ and Pi metabolism, it does not address the consequences of unregulated or dysregulated metabolism. Recently, the discovery of the phosphatonins has focused attention on phosph...
Thus, in phosphate homeostasis, the kidneys have a primary role. The filtered phosphate at the glomeruli is reabsorbed in the proximal tubules by Na+/PO43− cotransporters. The transport is driven by the intracellular Na+ gradient, which is maintained by Na+/K+-ATPase. Both PTH and a ...
(developmental) and phylogenic (evolutionary) timescales16. Thus, it is perhaps not surprising that a kind of multi-scale dynamic is in play in morphogenetic homeostasis: interactions between cells, known to be crucial for normal embryogenesis, have a parallel in the interaction between embryos in...