This is a 28-nucleotide 5′-UTR sequence in the ferritin mRNA , it is necessary for iron regulation. IRE sequences in the 3′UTR of the transferrin receptor mRNA protect the mRNA from degradation if the iron level is low. Iron is an essential element for many biological functions but ...
网络释义 1. 铁离子调控序列 CsFtn核苷酸序列中含一环颈结构类似序列,与铁离子调控序列(iron-responsive element)相似。CsFtn多肽序列与其它吸虫铁蛋 … www.chemyq.com|基于 1 个网页
Iron Responsive Element In the case of the IRE found in succinate dehydrogenase (SDHb) of Drosophila, the IRE is sufficient to mediate translational regulation of a chimeric gene expressed in mammalian cells and to shift the distribution of SDHb mRNA from polysomes (actively translated) to mRNPs...
All rights reserved.Keywords: Iron-regulatory proteins; Iron-responsive element; Ferritin; RNA-binding proteins; Posttranscriptional regulation1. IntroductionIron is an essential nutrient and a potentialtoxin. The cloning of the iron-regulatory proteins(IRPs) and understanding of their interactionwith iron...
Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close to the cap structure of mRNAs represses translation by precludi... E Paraskeva,NK Gray,B Schl?Ger,... - 《Molecular & Cellular Biology》 被引量: 277发表: 1999年 Multiple determinants within iron...
The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor). Expression of these ...
1) iron-responsive element (IRE) 铁反应元件 2) response elements 反应元件 1. METHODS: An chimeric promoter HRE Egr was generated by inserting the hypoxiaresponse elements(HREs) from human vascular endothelium growth factor 5′ flanking sequence into the upstream of human early growth response gene...
We report the cloning and functional characterization of the iron responsive element (IRE) of human ferritin light (L) chain mRNA from a cDNA library of primary human T lymphocytes. Comparison of this palindromic cDNA element to the IRE predicted from the reported genomic sequence revealed significa...
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They...
Iron regulatory factor (IRF), also called iron responsive element-binding protein (IRE-BP), is a cytoplasmic RNA-binding protein which regulates post-trans... Hirling,Emery-Goodman,Thompson,... - 《Nucleic Acids Research》 被引量: 47发表: 1992年 加载更多来源...