The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis. Little is known concerning how factors other than iron may modulate the activity...
The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and transferrin receptor). Expression of these ...
All rights reserved.Keywords: Iron-regulatory proteins; Iron-responsive element; Ferritin; RNA-binding proteins; Posttranscriptional regulation1. IntroductionIron is an essential nutrient and a potentialtoxin. The cloning of the iron-regulatory proteins(IRPs) and understanding of their interactionwith iron...
The iron-responsive element-binding protein (IRE-BP) binds to specific RNA stem-loop structures called iron-responsive elements (IREs), which mediate the post-transcriptional regulation of a variety of genes involved in iron metabolism. The IRE-BP is cytosolic aconitase, and a [4Fe-4S] cubane...
In recent reports attention has been drawn to the extensive amino acid homology between pig heart, yeast, and Escherichia coli aconitases (EC 4.2.1.3) and the iron-responsive element binding protein (IRE-BP) of mammalian cells [Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J....
Iron regulatory factor (IRF), also called iron responsive element-binding protein (IRE-BP), is a cytoplasmic RNA-binding protein which regulates post-trans... Hirling,Emery-Goodman,Thompson,... - 《Nucleic Acids Research》 被引量: 47发表: 1992年 加载更多来源...
Iron-responsive element‒binding proteins (IRP1 and IRP2) bind to the iron-responsive element (IRE) in the untranslated region (UTR) of mRNAs encoding various iron-regulating molecules, thereby regulating their translation. ALAS2: aminolevulinic acid synthase 2; DMT1: divalent metal transporter 1...
In addition to its critical roles in many enzymatic reactions11,12,13, iron directly regulates gene expression to enable the rapid response of cells to environmental cues14,15,16. The most well-characterized iron-regulated genes contain iron-responsive elements (IREs), which are conserved short st...
Divalent metal ion transporter 1 Natural resistance associated macrophage protein 2 Iron responsive element Iron regulatory protein Iron Abbreviations DCT1, divalent cation transporter 1 DMT1, divalent metal ion transporter 1 IRE, iron responsive element IRP, iron regulatory protein ...
Additionally, in support of this connection, suppressing the iron metabolism master regulator IREB2 (iron-responsive element-binding protein 2) decreases sensitivity to ferroptosis14. To better understand these interrelationships, we specify that the IREB2 gene is involved in encoding the iron-responsive...