Akiyama, S. K., Yamada, S. S., Chen, W. T. & Yamada, K. M. Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.J. Cell Biol.109, 863–875 (1989). ArticleCASPubMedGoogle Scholar Mould, A...
Advances in Molecular and Cell BiologyPalecek SP, Cox EA, Huttenlocher A, Lauffenburger DA, Horwitz AF. Integrin adhesion in cell migration. In: Bittar EE, Garrod DR, North AJ, Chidgey MAJ, editors. Advances in Molecular and Cell Biology. Vol. 28. Stamford, CT: JAI Press; 1999. pp. ...
Integrins have key functions in cell adhesion and migration. How integrins are dynamically relocalized to the leading edge in highly polarized migratory cells has remained unexplored. Here, we demonstrate that β1 integrin (known as PAT-3 in Caenorh
The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking. This is a preview of subscription content, ...
While several former results were confirmed, others were contradicted and new functions found, significantly changing the previous view of beta1 integrin function in vivo. 展开 关键词: Antigens, CD29 Cell Adhesion Molecules Cell Differentiation Cell Movement Extracellular Matrix Proteins Hematopoiesis ...
Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein ...
aCell adhesion molecules integrin αV can influence the radiosensitivity of human nasopharyngeal carcinoma CNE-2Z cells and the inhibition of cell apoptosis might be its mechanism, proved by three dimensional culture model to mimic solid tumor in vivo. 细胞粘着分子integrin αV可能影响人的鼻咽癌CNE-2Z...
enhancedJurkatE6celladhesionstimulatedbyFN.Wearegoingtoexploretheroleofα4integrininimpactingthefunctionofLPXNinfollow-upexperiments,suchasphosphorylationofLPXNandtheLPXNmediatedcelladhesionandmigration.Keywordsα4integrin,LPXN,FN,celladhension,recombinantplasmid前言细胞的粘附是存在于生物体内的很重要的生命现象,它参与...
Expression of CD38 and CD43 was analyzed on the gated CD34+ cell population by FACScan. CD43 enhanced-adhesion to fibronectin is integrin-dependent in MO7e and cord blood CD34+ cells To test if CD43 enhanced-adhesion to fibronectin was mediated by integrin, function-blocking anti-integrin ...
Focal adhesion kinase regulates ??1 integrin-dependent T cell migration through an HEF1 effector pathway Although β1 integrin-dependent T cell migration is required for immune function, little is known of the signaling pathways regulating this migration. We n... GijsA.van Seventer,HeinzJ. Salme...