During the inflammatory responses, leukocytes are recruited at the site of high endothelial venule, roll over the endothelium surface, form the firm adhesion to spread out, and finally transmigrate across the blood vessel to the inflammatory site. Similar cascade is also found in tumor metastasis ...
Loss of cell adhesion during malignant transformation In the classic view of malignant transformation in the epithelium, cells lose their dependence on integrin-mediated interactions with the extracellular matrix and resulting signaling events (Fig. 1C). During this process, adherens junctions that are ...
These pathways may help fibroblasts to adhere to surrounding cells, such as “positive regulation of cell adhesion mediated by integrin” and “cell junction maintenance”, “keratinization”, “hair follicle maturation”, and “epithelial mesenchymal cell signaling”, and so on (Fig. 5c, d). Up...
(1995). Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem. Biophys. Res... H Yano,Y Mazaki,K Kurokawa,... - 《Journal of Cell Biology》 被引量: 0发表: 2004年 Roles Played by a Subset of Integrin Signalin...
Cell adhesion to the extracellular matrix is generally mediated by integrin receptors, which bind to intracellular adhesion proteins that form multi-molecular scaffolding and signalling complexes. The networks of proteins, and their interactions, are dynamic, mechanosensitive and extremely complex. Recent ef...
In REF52 cells, we have observed that activation of MAP kinases is accompanied by redistribution of the protein to the nucleus, suggesting that the activated kinases may impinge on factors regulating gene expression. Thus, integrin-mediated cell adhesion seems a sufficient stimulus to cause ...
Integrin cell adhesion is mediated by proteins generated by epithelial cells in the extracellular matrix known as thebasal lamina. Integrins use adaptor proteins like plectins and BP230 to attach the extracellular matrix to keratin intermediate filaments. ...
cell adhesionAtom RSS Feed Cell adhesion articles within Scientific Reports FeaturedArticle 31 October 2024 | Open Access TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1 Xingnan Zhang , Chenhao Hu & Song ...
Cell adhesion is the binding of a cell to a surface, extracellular matrix (ECM), or another cell using cell adhesion molecules, which are integral membrane proteins that have cytoplasmic, transmembrane, and extracellular domains. The extracellular domains of adhesion molecules extend from the cell an...
The following sections are included:IntroductionIntegrin-mediated Cell AdhesionCellular Adhesion to Implanted BiomaterialsBiomimetic Materials for Tissue Engineering using ECM ProteinsPhysical adsorption of ECM proteins to biomaterialsInfluencing ECM protein adsorptionBiomimetic Materials for Tissue Engineering using EC...