The integrin subunit beta 5 has only been associated with the alpha v subunit to form the alpha v beta 5 heterodimer. This integrin mediates cell adhesion to vitronectin and also recognizes fibronectin when the integrin is activated. This integrin is found in a variety of cells in most normal...
A novel cell adhesion region in tropoelastin mediates attachment to integrin alphaVbeta5. J. Biol. Chem. 289, 1467-1477. doi: 10.1074/jbc.M113.518381Lee, P., Bax, D. V., Bilek, M. M. M., and Weiss, A. S. (2013) A novel cell adhesion region in tropoelastin that mediates ...
Embryonic stem (ES) cells have a broad potential application in regenerative medicine and can be differentiated into cells of all three germ layers. Adhesion of ES cells to extracellular matrix (ECM) proteins is essential for the differentiation pathway; Cell-ECM adhesion is mediated by integrins ...
Integrin alpha v/beta 5 complex also binds to the basic domain of Tat (he sequence RKKRRQRRR). The integrin beta 5 is found on carcinoma cell lines, hepatoma and fibroblast cell lines, and is absent from lymphoblastoid cells and platelets.The KN52 monoclonal antibody has been ...
Cell adhesion through integrins affects cell survival. We have uncovered a programmed cell death pathway triggered by internalization of VVISYSMPD, a β5 cytoplasmic domain binding peptide that mimics annexin V and affects PKC-dependent signaling. Identification of a Specific β5 Cytoplasmic Domain Bind...
In vitro adenoviral vector p53-mediated transduction and killing correlates with expression of coxsackie-adenovirus receptor and alpha(nu)beta5 integrin in SUDHL-1 cells derived from anaplastic large-cell lymphoma. Clin Cancer Res 2000; 6: 185–192. CAS PubMed Google Scholar Wattel E et al. ...
Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part...
Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signalin
integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in c...
Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signaling. 整合素α5抗体Integrin...