The density map for the unliganded α5β1 headpiece shows a 'closed' conformation similar to that seen in the αVβ3 crystal structure. By contrast, binding to fibronectin induces an 'open' conformation with a dramatic, ∼80° change in the angle of the hybrid domain of the β subunit...
A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Sci 1993; 105: 101–111. CAS PubMed Google Scholar Wayner EA, Orlando RA, Cheresh DA . Integrins alpha v beta 3 and alpha v beta 5 contribute to cell ...
The recently reported crystal structures of the extracellular domains of the alphavbeta3 integrin in its unligated state and in complex with the peptide cyclo(-RGDf[NMe]V-) have dramatically increased our understanding of ligand binding to integrins. Nonetheless, ligand selectivity toward different in...
structure.integrinα5β1Structures of N-linked oligosaccharides obtained from human integrin α5β1 are described. Integrin α5β1 (4.5 mg) was purified from human placenta and digested using trypsin and chymotrypsin. N-linked oligosaccharides were released from the glycopeptides by digestion with ...
Structure of Adenovirus Complexed with Its Internalization Receptor, αvβ5 Integrin The three-dimensional structure of soluble recombinant integrin alphavbeta5 bound to human adenovirus types 2 and 12 (Ad2 and -12) has been determined at a... CY Chiu,P Mathias,GR Nemerow,... - 《Journal of...
The AgNPs have a highly stable structure and photoluminescence, while they can be dissolved with a membrane-impermeable etchant, which allows one to eliminate extracellular particles and specifically visualize intracellular ones25. AgNPs coated with iRGD (iRGD-AgNPs) are 40 ± 10 nm in ...
Integrin α5β1 is a key receptor for the extracellular matrix protein fibronectin.Antagonists of human α5β1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. However, the structure of the integrin is unsolved and the atomic basis of fibronectin and antagon...
The structure and function of inte-grin was introduced.Integrin is a noncovalentassociated heterodimer composed of αand βmembrane-spanning subunits.It is involved inthe adhesion between cell and cell,cell andextracelluar matrix.The signal transductionoutside in was mediated by tyrosine kinase and...
It emphasizes the importance of the three-dimensional structure and the conformation of the intrgrin recognition sites within the ligands.关键词: Humans Parvovirus B19, Human Parvoviridae Infections Hydrops Fetalis DNA, Viral Polymerase Chain Reaction In Situ Hybridization Base Sequence Molecular Sequence...
During cerebral cortex development, post-mitotic neurons interact with radial glial fibers and the extracellular environment to migrate away from the ventricular region and form a correct laminar structure. Integrin receptors are major mediators of cell–cell and cell–extracellular matrix interactions. Sev...