Integrin receptors connect cells to the extracellular matrix, mediating cell interactions, adhesion and signalling. This Review discusses integrin function in cell migration, including integrin activation, integrin-based adhesion types and their roles in cancer cell dissemination. ...
In this review, we examine the control of integrin function by cell metabolism, and the impact of this regulation in cancer. Within this context, nutrient sufficiency or deprivation is sensed by a number of metabolic signaling pathways such as AMP-activated protein kinase (AMPK), mammalian target...
1999). In Drosophila, the finding that βPS3 is needed to maintain the germ-line stem cell niche has shown the importance of integrin-mediated events for early stem cell function (Tanentzapf et al. 2007). In vitro studies have revealed that cell adhesive interactions can provide signals that...
Integrins' lateral mobility and rearrangement is essential for integrins primary function of cell-extracellular matrix adhesion, cell-cell adhesion, and signaling. Lateral movement allows integrins to associate with extracellular ligand and other cytoplasmic and membrane proteins to incite biological activity ...
CONCLUSIONS: Integrin localization, production, and cell adhesion function in the stratified squamous epithelium of the cornea are not dramatically altered during epithelial cell migration over simple debridement wounds. Integrins in the cell membrane at sites of cell-cell interaction and as components of...
The involvement of lipid rafts in the regulation of integrin function J Cell Sci, 115 (2002), pp. 963-972 CrossrefView in ScopusGoogle Scholar [49] R. Wang, J. Bi, K.K. Ampah, C. Zhang, Z. Li, Y. Jiao, et al. Lipid raft regulates the initial spreading of melanoma A375 cells...
Cell Biol.10.1083/jcb.123.5.1289 Palmer, E.L., Ruegg, C., Ferrando, R., Pytela, R. and Sheppard, D. (1993) . 123, 1289–1297 Google Scholar 16. The primary structure of the α4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion functionEMBO J....
Integrins—A Versatile and Old Family of Cell Adhesion Molecules In multicellular organisms, cell-cell contacts within a tissue as well as contacts between cells and the extracellular matrix, which scaffolds the tissue, are indispensably required for the physiological function of the tissue and its ...
Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function. EMBO J. 26, 2832–2842 (2007). Article CAS PubMed PubMed Central Google Scholar Zutter, M. M., Santoro, S. A., Staatz, W. D. & Tsung, Y. L. Re-expression of the alpha 2 beta 1...
The increase in cell migration observed upon convertases inhibition appears to be due to the up-regulation of β1 integrins and to their location in larger focal-adhesion structures. The endoproteolytic cleavage of αv subunits is necessary for αvβ5/β6 integrin to control α2β1 function ...