Immune escape, a process by which tumor cells evade immune surveillance, remains a challenge for cancer therapy. Tumor cells produce extracellular vesicles (EVs) that participate in immune escape by transferring bioactive molecules between cells. EVs refer to heterogeneous vesicles that...
肿瘤免疫逃避(Tumor immune escape):有些肿瘤细胞具有逃避免疫机制的作用,可以使免疫细胞辨认不出谁是肿瘤细胞,因此 … ebiology.life.nthu.edu.tw|基于 1 个网页 3. 癌免疫逃脱 但这招数对子宫颈癌的癌细胞起不了多大作用。这个现象,叫「癌免疫逃脱」(Tumor Immune Escape)。
Activation of T cells could kill cancer cells leading to inhibition of tumor progression, while aberrant high levels of PD-L1 on cancer cells bind to PD-1 on T cells resulting in inhibition of T cell activity, consequently promoting tumor immune escape (1, 2). Therefore, inhibition of PD-...
According to the immunoediting theory, immune escape is the key to tumor survival.1There are many mechanisms of tumor immune escape (TIE), including defects in tumor antigen presentation to escape recognition by the immune system, alterations in the tumor death pathways to achieve increased resistanc...
Tumor immune microenvironmentCancerThe immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involves the degradation of damaged proteins...
Tumor-intrinsic mechanisms of immune escape in myeloma Recent pre-clinical and clinical studies support the strategy that triggering host immunity is critical for most anti-myeloma therapies to be effective [11,12,13,14]. PIs, IMiDs, monoclonal Abs (mAbs), autologous stem cell transplantation (ASC...
(anti-PD-L1) monoclonal antibodies3,4. In tumor biology, the PD-1/PD-L1 pathway is a mechanism of adaptive immune escape used by tumor cells in response to endogenous antitumor activity. When PD-L1 expressed on tumor cells binds to PD-1 receptors on immune cells, the interaction leads ...
Lang K,Entschladen F,Weidt Cet al.Tumor immune escape mecha-nisms:impact of the neuroendocrine system.Cancer Immunology Immunotherapy. 2006jIang K,Entsehladen F,Weidt C,et a1.Tmnor immune escape mecha-- nistm :impact of the neuroendocrine system[J].Cancer Immtmol Im. munother.2006,55(7)...
Oncology Investigation of immune escape paths in the tumor microenvironment UNIVERSITY OF SOUTHERN CALIFORNIA Alan Epstein ParkRyanFold changes in 113 genes were measured using RT-qPCR in B16, RENCA, and LLC tumors of syngeneic mice for mechanisms of immune escape. Fold changes were compared at Day...
肿瘤树突状细胞中鞘脂激活蛋白原的高糖基化促使免疫逃逸 DOI: 10.1126/science.adg1955 Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape | Science ③Science:Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand ...