These tumors have, however, evolved mecha- nisms to escape immune eradication. An effective way of escaping immune eradication is to prevent detection. The expression of tumor-associated antigens enhances the immunogenicity of a tumor, and if it is able to reduce the presentation of such markers...
Tumor immune escape mecha-nisms:impact of the neuroendocrine system. Lang K,Entschladen F,Weidt Cet al. Cancer Immunology Immunotherapy . 2006Kerstin Lang,Frank Entschladen,Corinna Weidt,Kurt S. Zaenker.Tumor immune escape mechanisms: impact of the neuroendocrine system[J]. Cancer Immunology, ...
In this paper we place the "exosome-immune suppression" concept in perspective of other tumor immune evasion mechanisms. We conclude by discussing a novel therapeutic approach to cancer immune suppression by extracorporeal removal of exosomes using hollow fiber filtration technology Cancer is Recognized b...
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1...
Since it was now accepted that the immune system is capable of eliminating tumor cells, targeting of immune escape mechanisms employed by tumors is an appealing therapeutic strategy. These mechanisms can be broadly divided into three main categories: loss of antigenicity, loss of immunogenicity, and...
However, cancer cells can sometimes escape these specific T-cell immune responses in the course of somatic (genetic and phenotypic) clonal evolution. Among the tumor immune escape mechanisms described to date, the alterations in the expression of major histocompatibility complex (MHC) molecules play ...
et al. Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Genome Biol. 16, 64 (2015). Article PubMed PubMed Central CAS Google Scholar Becht, E. et al. Immune and stromal classification of ...
T-cell and antibody-based therapies administer immune system components to act directly on the tumor or enhance existing immunity.145–147 However, most patients are insensitive to immunotherapy due to poor tumor immunogenicity and immune escape mediated by the tumor microenvironment.148 Immunotherapy ...
Kersten said the findings underscore that the phenotype and function ofimmune cellsin the context of cancer are heavily regulated byenvironmental factors, such as tissue stiffness and metabolic challenges. "Our findings help improve understanding of the mechanisms that regulate anti-tumor immune responses...
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